SHE9_ASPFU
ID SHE9_ASPFU Reviewed; 502 AA.
AC Q4WV30;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE Flags: Precursor;
GN Name=she9; ORFNames=AFUA_5G10600;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Required for the maintenance of the structure of the
CC mitochondrial inner membrane. Involved in mitochondrial morphology.
CC Causes growth arrest when highly overexpressed (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR EMBL; AAHF01000003; EAL91546.1; -; Genomic_DNA.
DR RefSeq; XP_753584.1; XM_748491.1.
DR AlphaFoldDB; Q4WV30; -.
DR SMR; Q4WV30; -.
DR STRING; 746128.CADAFUBP00005694; -.
DR EnsemblFungi; EAL91546; EAL91546; AFUA_5G10600.
DR GeneID; 3510974; -.
DR KEGG; afm:AFUA_5G10600; -.
DR VEuPathDB; FungiDB:Afu5g10600; -.
DR eggNOG; ENOG502QQ1E; Eukaryota.
DR HOGENOM; CLU_025632_2_0_1; -.
DR InParanoid; Q4WV30; -.
DR OMA; TTQREVT; -.
DR OrthoDB; 719853at2759; -.
DR Proteomes; UP000002530; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR InterPro; IPR008839; MDM33_fungi.
DR PANTHER; PTHR31961; PTHR31961; 1.
DR Pfam; PF05546; She9_MDM33; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..502
FT /note="Sensitive to high expression protein 9 homolog,
FT mitochondrial"
FT /id="PRO_0000351048"
FT TOPO_DOM ?..295
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..478
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 479..499
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 500..502
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT REGION 60..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 139..276
FT /evidence="ECO:0000255"
FT COMPBIAS 76..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 55938 MW; E2A7A0863A7150C8 CRC64;
MQPMPLLLRQ SLRSSANFAR TSLPIRPQFL PAAGPNLQPA REIQRSFSVC VRCQFRSQSP
LYSSPEKDTS KDDAATQQSK DGSSTLTPGD ESAKVEPDAE TQRPSPAAGE QDTLQGFYQD
AKNEPKRESA EKKGLPSYLE ERRSQLSKQF TEMMDNLQSN IFVAGQRLND LTGYSAIEAL
KKDIQLQEER LREARQRVRE AKNAYAAAIN RRSASQREVN ELLQRKHAWS AADLERFTHL
YRNDHTNEVA EMETQEALSA AERESEEAAA QLSKSILSRY HEEQVWSDKI RRMSTWGTWG
LMGVNVLLFL VFQIAVEPWR RKRLVKGFEE KVIEAIEKEK AINHIEILKP QPALTSTSPS
SKEEAAEPTP TSTAAGDTPT TDESTPAATD ETITSEPVVW DSDPIPTFVT NITAEIATET
TEDSAPKSAT INGVEPRKSQ LSRILPPLPP PTSLDSWRHT LNELFSDRSM VITQRDLTTV
ALQSAAAGAA IMGLVIALIR PR
