SHE9_CANAL
ID SHE9_CANAL Reviewed; 524 AA.
AC Q5A0L7; A0A1D8PGS0; Q9P865;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE Flags: Precursor;
GN Name=SHE9; OrderedLocusNames=CAALFM_C203050WA;
GN ORFNames=CaO19.13218, CaO19.5796;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11378898; DOI=10.1002/yea.716;
RA Andaluz E., Coque J.J., Cueva R., Larriba G.;
RT "Sequencing of a 4.3 kbp region of chromosome 2 of Candida albicans reveals
RT the presence of homologues of SHE9 from Saccharomyces cerevisiae and of
RT bacterial phosphatidylinositol-phospholipase C.";
RL Yeast 18:711-721(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Required for the maintenance of the structure of the
CC mitochondrial inner membrane. Involved in mitochondrial morphology.
CC Causes growth arrest when highly overexpressed (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR EMBL; AJ277539; CAB92912.1; -; Genomic_DNA.
DR EMBL; CP017624; AOW27342.1; -; Genomic_DNA.
DR RefSeq; XP_715337.1; XM_710244.2.
DR AlphaFoldDB; Q5A0L7; -.
DR SMR; Q5A0L7; -.
DR STRING; 237561.Q5A0L7; -.
DR PRIDE; Q5A0L7; -.
DR GeneID; 3642984; -.
DR KEGG; cal:CAALFM_C203050WA; -.
DR CGD; CAL0000193129; SHE9.
DR VEuPathDB; FungiDB:C2_03050W_A; -.
DR eggNOG; ENOG502QQ1E; Eukaryota.
DR HOGENOM; CLU_025632_5_0_1; -.
DR InParanoid; Q5A0L7; -.
DR OrthoDB; 719853at2759; -.
DR PRO; PR:Q5A0L7; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR InterPro; IPR008839; MDM33_fungi.
DR PANTHER; PTHR31961; PTHR31961; 2.
DR Pfam; PF05546; She9_MDM33; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..524
FT /note="Sensitive to high expression protein 9 homolog,
FT mitochondrial"
FT /id="PRO_0000351052"
FT TOPO_DOM ?..391
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 413..502
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 503..523
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 524
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT REGION 94..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 92..133
FT /evidence="ECO:0000255"
FT COILED 270..304
FT /evidence="ECO:0000255"
FT COILED 338..371
FT /evidence="ECO:0000255"
FT CONFLICT 19
FT /note="A -> P (in Ref. 1; CAB92912)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="E -> Q (in Ref. 1; CAB92912)"
FT /evidence="ECO:0000305"
FT CONFLICT 306
FT /note="Q -> L (in Ref. 1; CAB92912)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 524 AA; 60747 MW; B3A7B44A3430E48E CRC64;
MNLFVALSKK KKYQHKLFAP YLRPSTDTTT TETRFMLSTC LIRNCVFIRP RLSVICFKAI
RYQSKKSDFP DYTKINDPKL REIIEGSNFG TEAILKKQRE DQDKKKKMEQ ERKRLEQERE
VDRRREEKRA KEESESNKTD NDNEANQHTD DKLAKVNEKL ESNFSKTESG KLRGEDTGTR
ETVVETEEEE ELKLKAENKI IATSKDSVDE SDIPNLAKEI NETIQKEIAG LPSQKAKNQS
KLAKNLTKYL DSAHDTILTA TRALNDVTGY SAIEKLKKSI ETQEDDLKKA KEKVKQCKIA
YGEAIQRRSH SQREVNELLT RKHNWSSNDL ERFTELYRND HENEIHEQEA EKKLDEAESK
VDGVQLKLTQ SILTRYHEEQ IWSDKIRRSS TWGTWVLMGL NVLLFVVATF IVEPWKRSKL
VSAFEDKVKQ VLVGISQENE QILDPIIEKL EPTDGQVPIK TSFDFKFVTN TWHGLKAALV
RNYEALMSPE ITNLEFDKFE FELFTMTVAI VAFSMGSLIV SLFK
