ID   SHE9_CANGA              Reviewed;         405 AA.
AC   Q6FK33;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=SHE9; OrderedLocusNames=CAGL0M01518g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62387.1; -; Genomic_DNA.
DR   RefSeq; XP_449411.1; XM_449411.1.
DR   AlphaFoldDB; Q6FK33; -.
DR   SMR; Q6FK33; -.
DR   STRING; 5478.XP_449411.1; -.
DR   EnsemblFungi; CAG62387; CAG62387; CAGL0M01518g.
DR   GeneID; 2891180; -.
DR   KEGG; cgr:CAGL0M01518g; -.
DR   CGD; CAL0136279; SHE9.
DR   VEuPathDB; FungiDB:CAGL0M01518g; -.
DR   eggNOG; ENOG502QQ1E; Eukaryota.
DR   HOGENOM; CLU_679710_0_0_1; -.
DR   InParanoid; Q6FK33; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007007; P:inner mitochondrial membrane organization; IEA:EnsemblFungi.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..405
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000351053"
FT   TOPO_DOM        ?..281
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..381
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        403..405
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   COILED          76..118
FT                   /evidence="ECO:0000255"
FT   COILED          161..194
FT                   /evidence="ECO:0000255"
FT   COILED          230..261
FT                   /evidence="ECO:0000255"
FT   COILED          321..347
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   405 AA;  47733 MW;  5D0C513CE0B2A61F CRC64;
     MYSYRYLRPV SRSGRAILIQ RQAYLRNITF THFRCEENKS SASKRPTGNA LNTKLNELNG
     SLNNLWNKFL EGRGVFQHHA KNIRKSIQEA NKKIAEQEKE SKDAKINYKK DELTNEEIKD
     LPSERELHRK KWSRKLEFYL DSLQETLFTA TKALNDVTGY SSIQKLKNSI NLINEKLDAT
     RKARTDLKLQ YTKAIESRTL SQKQLNELLQ RKSSWSPSDL ENFTKLYKDD AINQQTEKEL
     KEKVRDIEKK EEQLTDDLYR AILTRYHEEQ IWSDKIRRTS TWGTFILMGF NLVLFIIFQL
     LLEPWKRRRL TGSFEGKVRH ALELHSQEQE TKIRDFLEEI KTKESNNIAN EQKTITKLSF
     WDKLRNTFQN STGLSLTQFN MLELTVTAIN SFLVGILFTL LLHAL