ID   SHE9_COCIM              Reviewed;         488 AA.
AC   Q1E9R5; J3KHN6;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=SHE9; ORFNames=CIMG_00698;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS35344.3; -; Genomic_DNA.
DR   RefSeq; XP_001246927.2; XM_001246926.2.
DR   AlphaFoldDB; Q1E9R5; -.
DR   SMR; Q1E9R5; -.
DR   STRING; 246410.Q1E9R5; -.
DR   PRIDE; Q1E9R5; -.
DR   EnsemblFungi; EAS35344; EAS35344; CIMG_00698.
DR   GeneID; 4565738; -.
DR   KEGG; cim:CIMG_00698; -.
DR   VEuPathDB; FungiDB:CIMG_00698; -.
DR   InParanoid; Q1E9R5; -.
DR   OMA; TTQREVT; -.
DR   OrthoDB; 719853at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..65
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           66..488
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000351054"
FT   TOPO_DOM        66..299
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        321..464
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        486..488
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   REGION          66..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          343..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          179..212
FT                   /evidence="ECO:0000255"
FT   COILED          250..279
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        84..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..403
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  54255 MW;  C8762080EC75D18E CRC64;
     MHTLPLLFRH SLRTGAGFAK STSPNHVSTT SFVVKLAPPR QRSRLGYVDA SICLRCQFRA
     QTRFYSVQGD GGGSGKENKE GGSLEGGNPT SSTDAKRDQT SSPDSSSALK SSDKSQAEES
     KDGPESRKED SEAETGGSLP SHWESRRSHL SKQFSQLMDN LQSNIFIANR HLNDLTGYSA
     IEALKKNIVA QEEHVRQTRT RVREAKDAYS AAINRRSASQ REVNELLQRK HAWTPTDLER
     FTSLYRSDHA NERAETEAQD ALMAAEREAE EAAGLLSKSI LSRYHEEQIW SDKIRRMSTW
     GTWGLMGVNV LLFLIFQVAV EPWRRKRLVK GFEEKVMEAI EKENGAQKEH AELEGKPAVE
     VTPPAVQTQR LTEELASEDQ GENIPTFTSA APSDLSSQEM QPGLPIQPEI EPEPEPEPEP
     EPIVEPPLTT ILPPEASLSP DSWQQTFRDL FSERRVTLSQ RDLTTVALES AAAGAAVMGV
     LIAIFRPR