ID   SHE9_CRYNB              Reviewed;         477 AA.
AC   P0CR47; Q55PC7; Q5KE29;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=SHE9; OrderedLocusNames=CNBG2850;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; AAEY01000038; EAL19657.1; -; Genomic_DNA.
DR   RefSeq; XP_774304.1; XM_769211.1.
DR   AlphaFoldDB; P0CR47; -.
DR   SMR; P0CR47; -.
DR   EnsemblFungi; EAL19657; EAL19657; CNBG2850.
DR   GeneID; 4937320; -.
DR   KEGG; cnb:CNBG2850; -.
DR   VEuPathDB; FungiDB:CNBG2850; -.
DR   HOGENOM; CLU_580048_0_0_1; -.
DR   Proteomes; UP000001435; Chromosome 7.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..477
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000410285"
FT   TOPO_DOM        ?..310
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        332..454
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        476..477
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   REGION          49..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          190..233
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        94..128
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   477 AA;  52353 MW;  7402DC721DA28A5A CRC64;
     MACRYPFSPA KVAITRFFYP SPLSRSTTPL FCPPSCRIRV GNTSRMLTSS SSVASENPKS
     EMAKFLASPN PKSSASEPGP SPHDVLSAPT SAGHISEAEE TLSDQLRNPG SSSSSSPSQS
     STNNLSSKNA PFKLSSTYSL PSNISVPPEV REHLIEWSKN VLEHSRYVIQ EAQKKFVGLG
     LKVNEMTGYQ EVERLKYMVF EKEDELQRLR EHARTAKAAY DEAVAARSEA QRETNILLER
     KHSWTDADVS KFTSLVRSDH TSSHAVASTS IALKDAEIAV DKSFSQLMQV ILQRYHEEQV
     WSDKIRSVST WANVAGLAIN FIIFVGAVLL VEPWKRKRLV EKLEERVASM MERVDHRLEG
     VEGHLERVAA GSASASAIKE QHSDAAIQGV EDMPSNSTAN PLEFVSPQTI PLMAAVDPTI
     NGSESQSDPF FTQTIRGFPN YLDPLVKPSQ KRDLAVAGMA GAVAAWILIG AVRLVRA