ID   SHE9_CRYNJ              Reviewed;         477 AA.
AC   P0CR46; Q55PC7; Q5KE29;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=SHE9; OrderedLocusNames=CNG01940;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; AE017347; AAW44580.1; -; Genomic_DNA.
DR   RefSeq; XP_571887.1; XM_571887.1.
DR   AlphaFoldDB; P0CR46; -.
DR   SMR; P0CR46; -.
DR   STRING; 5207.AAW44580; -.
DR   PaxDb; P0CR46; -.
DR   EnsemblFungi; AAW44580; AAW44580; CNG01940.
DR   GeneID; 3258684; -.
DR   KEGG; cne:CNG01940; -.
DR   VEuPathDB; FungiDB:CNG01940; -.
DR   eggNOG; ENOG502QQ1E; Eukaryota.
DR   HOGENOM; CLU_580048_0_0_1; -.
DR   InParanoid; P0CR46; -.
DR   OMA; EDPKSEM; -.
DR   OrthoDB; 711872at2759; -.
DR   Proteomes; UP000002149; Chromosome 7.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..477
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000351055"
FT   TOPO_DOM        ?..310
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        332..454
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        476..477
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   REGION          45..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          190..233
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        94..128
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   477 AA;  52354 MW;  4DF9194B7B84C9AF CRC64;
     MACRYPFSPA KVAITRFFYP SPLSRSTTPL FCPPSCRIRV GNTSRMLTSS SSVASEDPKS
     EMAKFLASPN PKSSASEPGP SPHDVLSAPT SAGHISEAEE TLSDQLRNPG SSSSSSPSQS
     STNNLSSKNA PFKLSSTYSL PSNISVPPEV REHLIEWSKN VLEHSRYVIQ EAQKKFVGLG
     LKVNEMTGYQ EVERLKYMVF EKEDELQRLR EHARTAKAAY DEAVAARSEA QRETNILLER
     KHSWTDADVS KFTSLVRSDH TSSHAVASTS IALKDAEIAV DKSFSQLMQV ILQRYHEEQV
     WSDKIRSVST WANVAGLAIN FIIFVGAVLL VEPWKRKRLV EKLEERVASM MERVDHRLEG
     VEGHLERVAA GSASASAIKE QHSDAAIQGV EDMPSNSTAN PLEFVSPQTI PLMAAVDPTI
     NGSESQSDPF FTQTIRGFPN YLDPLVKPSQ KRDLAVAGMA GAVAAWILIG AVRLVRA