ID   SHE9_KLULA              Reviewed;         411 AA.
AC   Q6CUA2;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=SHE9; OrderedLocusNames=KLLA0C06512g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01338.1; -; Genomic_DNA.
DR   RefSeq; XP_452487.1; XM_452487.1.
DR   AlphaFoldDB; Q6CUA2; -.
DR   SMR; Q6CUA2; -.
DR   STRING; 28985.XP_452487.1; -.
DR   EnsemblFungi; CAH01338; CAH01338; KLLA0_C06512g.
DR   GeneID; 2891905; -.
DR   KEGG; kla:KLLA0_C06512g; -.
DR   eggNOG; ENOG502QQ1E; Eukaryota.
DR   HOGENOM; CLU_025632_5_1_1; -.
DR   InParanoid; Q6CUA2; -.
DR   OMA; DIWERIK; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007007; P:inner mitochondrial membrane organization; IEA:EnsemblFungi.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..411
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000351058"
FT   TOPO_DOM        ?..270
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..411
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   COILED          69..103
FT                   /evidence="ECO:0000255"
FT   COILED          148..250
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   411 AA;  48248 MW;  8F862EB43F965C8E CRC64;
     MLVRRIIVRL PSSPRVWTQY NPRIFYSTGP NTNSTLVDTW KQKLGAYWEK SQNKANETAN
     KLREYSVNFK TQWDKAQKSL KDANERLSQM ENDSNDSKLN YNAEGKIKDL PSERERHRKK
     WARKMELYLD SLQETIFTAT RALNDVTGYS SIQKLRNTIS SLEEELKDTK KLVNEAKEKY
     ETAIKARSGS QKEVNELLQR KNSWSPTDLD RFTQLYRDDA LNSQTEEQSK VKLAELEAKE
     EELSTNLYRA ILTRYHEEQI WSDKIRRTST WGTFILMGVN ILFFVIFQLL LEPWKRRRLV
     GSFEDKVKMA LDDHQKEQNL AISEMSNTID NLMDKKLQET QTKPHQEEVP KILTFSNIVA
     DFKIWCSLQW TIYYNKLVTL LPETTVTFTK SCFYSYSTLL LSLGILLGHC I