ID   SHE9_NEOFI              Reviewed;         502 AA.
AC   A1DEC4;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=she9; ORFNames=NFIA_076610;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; DS027696; EAW17731.1; -; Genomic_DNA.
DR   RefSeq; XP_001259628.1; XM_001259627.1.
DR   AlphaFoldDB; A1DEC4; -.
DR   SMR; A1DEC4; -.
DR   STRING; 36630.CADNFIAP00007405; -.
DR   EnsemblFungi; EAW17731; EAW17731; NFIA_076610.
DR   GeneID; 4585958; -.
DR   KEGG; nfi:NFIA_076610; -.
DR   VEuPathDB; FungiDB:NFIA_076610; -.
DR   eggNOG; ENOG502QQ1E; Eukaryota.
DR   HOGENOM; CLU_025632_2_0_1; -.
DR   OMA; TTQREVT; -.
DR   OrthoDB; 719853at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..502
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000351060"
FT   TOPO_DOM        ?..295
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        317..478
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        479..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        500..502
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   REGION          58..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          350..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          139..275
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        117..139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..391
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   502 AA;  56220 MW;  F2A82E3D3933B889 CRC64;
     MQPMPLLLRQ SLRSSANFAR TSLPIRPQFL PAAGPNIRPA RDIQRSFSVC VRCQFRSQSP
     SYSSPEKDTL KDDAATRQSK DASSTLTPRD ESPKVEPDAE TQRPSPAAGE QDTLQGFDQD
     AKNEPKREPA EKKGLPSYLE ERRSQLSKQF TEMMDNLQSN IFVAGQRLND LTGYSAIEAL
     KKDIQLQEER LREARQRVRE AKDAYAAAIN RRSASQREVN ELLQRKHAWS AADLERFTHL
     YRNDHTNEVA EMETQDALSA AERESEEAAA QLSKSILSRY HEEQVWSDKI RRMSTWGTWG
     LMGVNVLLFL VFQIAVEPWR RKRLVKGFEE KVIEAIEKEK AINHIEILKP QPALTSTSPS
     SKEEAAEPTP TSTATKDTPT TDENTPAATD EAITSEPVVW DSDPTPTIVT NITPETATET
     TEDSAPKSAT INLVEPRKPH LSRILPPLPP STSLDSWRQT LNELFSDRSM VITQRDLTTV
     TLQSAAAGAA IMGLVIALIR PR