SHE9_NEUCR
ID SHE9_NEUCR Reviewed; 553 AA.
AC Q7S9I1;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE Flags: Precursor;
GN Name=she-9; ORFNames=NCU06546;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Required for the maintenance of the structure of the
CC mitochondrial inner membrane. Involved in mitochondrial morphology.
CC Causes growth arrest when highly overexpressed (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR EMBL; CM002239; EAA33017.1; -; Genomic_DNA.
DR RefSeq; XP_962253.1; XM_957160.2.
DR AlphaFoldDB; Q7S9I1; -.
DR STRING; 5141.EFNCRP00000006295; -.
DR EnsemblFungi; EAA33017; EAA33017; NCU06546.
DR GeneID; 3878411; -.
DR KEGG; ncr:NCU06546; -.
DR VEuPathDB; FungiDB:NCU06546; -.
DR HOGENOM; CLU_025632_1_0_1; -.
DR InParanoid; Q7S9I1; -.
DR OMA; TTQREVT; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR InterPro; IPR008839; MDM33_fungi.
DR PANTHER; PTHR31961; PTHR31961; 1.
DR Pfam; PF05546; She9_MDM33; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..553
FT /note="Sensitive to high expression protein 9 homolog,
FT mitochondrial"
FT /id="PRO_0000351061"
FT TOPO_DOM ?..330
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352..523
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 545..553
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT REGION 61..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 210..241
FT /evidence="ECO:0000255"
FT COILED 277..309
FT /evidence="ECO:0000255"
FT COMPBIAS 66..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 60871 MW; F5DEDD5C689E3564 CRC64;
MSSTTAIRLA ARPSSWRGTG ALSSGRPLSQ FASLPRRSIN PSISGMRQGT LRLSIHDGRL
FFSTQPPKDT PENMNNKETG SSNVIFMPPP PPAQTEAPSS GSAKEDTTDA TNKSETETPT
AASESETSKS SESDVSSAST SDSANSSETT TTTSETTPEN GNNDTAQPEL PSRTEAHRAR
LSARFSTIMD NFQTRLLTAT QTLNDLTGYS AIEQIKRKNA ELEVAHGQAQ SRLRDARHNY
KSLTMHRAST QREVTTLLAR KDTWNPLDLE RFTSLYRLDH ELEAQVAQAA QELTEAETEE
SRLSADLNAG ILKRYHEEQI WSDRIRRQST WGTWGLMGVN VLLFLVLQFV AEPWRRKRLM
KGIAENEKGV IDEVRHELGQ VRQALEASGL RETAHLARLM EQEREIQALA STSSSSGDPQ
GGGGRTEGEV EMDIGAEFMA AAAEEAAEEA ATAQQQQQQQ QQQQQQQHHQ TPETQEEPQQ
PPLTWKQTAQ KWQQTLSDPQ QIKAAVVDLY SDRRIDLKMR DVSLLALESA ATGAAVVASV
AFFVLRSSGS GKA
