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SHE9_PICGU
ID   SHE9_PICGU              Reviewed;         440 AA.
AC   A5DI86;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=SHE9; ORFNames=PGUG_02987;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; CH408157; EDK38889.2; -; Genomic_DNA.
DR   RefSeq; XP_001485258.1; XM_001485208.1.
DR   AlphaFoldDB; A5DI86; -.
DR   SMR; A5DI86; -.
DR   STRING; 4929.XP_001485258.1; -.
DR   PRIDE; A5DI86; -.
DR   EnsemblFungi; EDK38889; EDK38889; PGUG_02987.
DR   GeneID; 5126995; -.
DR   KEGG; pgu:PGUG_02987; -.
DR   VEuPathDB; FungiDB:PGUG_02987; -.
DR   eggNOG; ENOG502QQ1E; Eukaryota.
DR   HOGENOM; CLU_025632_5_0_1; -.
DR   InParanoid; A5DI86; -.
DR   OMA; HQANADE; -.
DR   OrthoDB; 719853at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..35
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..440
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000351062"
FT   TOPO_DOM        36..302
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        324..416
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        438..440
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   REGION          87..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          180..215
FT                   /evidence="ECO:0000255"
FT   COILED          259..283
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   440 AA;  49435 MW;  76DBC36350873150 CRC64;
     MNSTNMSLKF RSRSAISVAL VDQLMFATTI AIARGIRLCA GRSQYLAATC TPSRFVNKFQ
     VRSSSNSKNI DDKLQTIIDS SNLGAVKKQN EANNKSRNAS DTVNDTNTAI PSSSETFHQA
     NADEHTISES TKRAILAENP TLPSQRERLR TETSKRIETY LESLQKTIFR ATRTLNDATG
     YSSIEGLKNE VEKLEIELRR AKTTVKECKK AYTDAISVRS QSQQEVNELL TRKHNWSPSD
     LERFTELYRN DHTNEQLEAE AARKLTDAES KVDSIQLKLT QSILTRYHEE QIWSDKIRSA
     STWGTWVIMG INVLLFFVAT LIVEPWKRKR LVASFEDKVK VAISEVNLSN TDSVVEKNTI
     PAPEASALNE TSFSSQISLE PSLLSLSWSQ WTWTKFSNYV KSTTSRVLYG NGEIQAIDAR
     LLLVISTFLG CILGNILSGR
 
 
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