SHE9_PICGU
ID SHE9_PICGU Reviewed; 440 AA.
AC A5DI86;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE Flags: Precursor;
GN Name=SHE9; ORFNames=PGUG_02987;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Required for the maintenance of the structure of the
CC mitochondrial inner membrane. Involved in mitochondrial morphology.
CC Causes growth arrest when highly overexpressed (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR EMBL; CH408157; EDK38889.2; -; Genomic_DNA.
DR RefSeq; XP_001485258.1; XM_001485208.1.
DR AlphaFoldDB; A5DI86; -.
DR SMR; A5DI86; -.
DR STRING; 4929.XP_001485258.1; -.
DR PRIDE; A5DI86; -.
DR EnsemblFungi; EDK38889; EDK38889; PGUG_02987.
DR GeneID; 5126995; -.
DR KEGG; pgu:PGUG_02987; -.
DR VEuPathDB; FungiDB:PGUG_02987; -.
DR eggNOG; ENOG502QQ1E; Eukaryota.
DR HOGENOM; CLU_025632_5_0_1; -.
DR InParanoid; A5DI86; -.
DR OMA; HQANADE; -.
DR OrthoDB; 719853at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008839; MDM33_fungi.
DR PANTHER; PTHR31961; PTHR31961; 1.
DR Pfam; PF05546; She9_MDM33; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..35
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 36..440
FT /note="Sensitive to high expression protein 9 homolog,
FT mitochondrial"
FT /id="PRO_0000351062"
FT TOPO_DOM 36..302
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..416
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 438..440
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT REGION 87..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 180..215
FT /evidence="ECO:0000255"
FT COILED 259..283
FT /evidence="ECO:0000255"
SQ SEQUENCE 440 AA; 49435 MW; 76DBC36350873150 CRC64;
MNSTNMSLKF RSRSAISVAL VDQLMFATTI AIARGIRLCA GRSQYLAATC TPSRFVNKFQ
VRSSSNSKNI DDKLQTIIDS SNLGAVKKQN EANNKSRNAS DTVNDTNTAI PSSSETFHQA
NADEHTISES TKRAILAENP TLPSQRERLR TETSKRIETY LESLQKTIFR ATRTLNDATG
YSSIEGLKNE VEKLEIELRR AKTTVKECKK AYTDAISVRS QSQQEVNELL TRKHNWSPSD
LERFTELYRN DHTNEQLEAE AARKLTDAES KVDSIQLKLT QSILTRYHEE QIWSDKIRSA
STWGTWVIMG INVLLFFVAT LIVEPWKRKR LVASFEDKVK VAISEVNLSN TDSVVEKNTI
PAPEASALNE TSFSSQISLE PSLLSLSWSQ WTWTKFSNYV KSTTSRVLYG NGEIQAIDAR
LLLVISTFLG CILGNILSGR