SHE9_SCHPO
ID SHE9_SCHPO Reviewed; 317 AA.
AC Q9P6N3;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE Flags: Precursor;
GN Name=she9; ORFNames=SPAC823.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for the maintenance of the structure of the
CC mitochondrial inner membrane. Involved in mitochondrial morphology.
CC Causes growth arrest when highly overexpressed (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB90158.1; -; Genomic_DNA.
DR RefSeq; NP_593840.1; NM_001019269.2.
DR AlphaFoldDB; Q9P6N3; -.
DR SMR; Q9P6N3; -.
DR BioGRID; 279658; 11.
DR STRING; 4896.SPAC823.13c.1; -.
DR MaxQB; Q9P6N3; -.
DR PaxDb; Q9P6N3; -.
DR EnsemblFungi; SPAC823.13c.1; SPAC823.13c.1:pep; SPAC823.13c.
DR GeneID; 2543230; -.
DR KEGG; spo:SPAC823.13c; -.
DR PomBase; SPAC823.13c; she9.
DR VEuPathDB; FungiDB:SPAC823.13c; -.
DR eggNOG; ENOG502QQ1E; Eukaryota.
DR HOGENOM; CLU_025632_2_2_1; -.
DR InParanoid; Q9P6N3; -.
DR OMA; LYREDYS; -.
DR PhylomeDB; Q9P6N3; -.
DR PRO; PR:Q9P6N3; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; ISS:PomBase.
DR InterPro; IPR008839; MDM33_fungi.
DR PANTHER; PTHR31961; PTHR31961; 2.
DR Pfam; PF05546; She9_MDM33; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..317
FT /note="Sensitive to high expression protein 9 homolog,
FT mitochondrial"
FT /id="PRO_0000351063"
FT TOPO_DOM ?..165
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..294
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..317
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT COILED 45..145
FT /evidence="ECO:0000255"
SQ SEQUENCE 317 AA; 36750 MW; ACF2B0C17B0E2059 CRC64;
MLQRLSQSIK GFAARFPKIY NKGNGSVQQT ILQASQRLNE LTGYSSIEAL KNAVVKQETK
LRDFRLSAAE ARKRYIEAVE KRSSSQREVN ELLQRRSSWS TIDLERFTKL YRDDYSNKEE
EIKAQEDVDV AERRVEEAQN GLVRSILSRY HEEQVWSDKI RQASTWGTWG LMGINVVLFV
VVQLILEPRK RKRLVREAVD HIDKERELEI NDELKKISEK LDKKGEAVGQ ALELTSPKID
NKNLPKNSAS LILPPINYDT FHSFLDSLKY FLSRFLSTDY RIQLTYRQLS ILATKFTVGG
GVIIYTFIHL FGLAFKR
