ID   SHE9_VANPO              Reviewed;         446 AA.
AC   A7THM1;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=SHE9; ORFNames=Kpol_543p16;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; DS480392; EDO18187.1; -; Genomic_DNA.
DR   RefSeq; XP_001646045.1; XM_001645995.1.
DR   AlphaFoldDB; A7THM1; -.
DR   SMR; A7THM1; -.
DR   STRING; 436907.A7THM1; -.
DR   EnsemblFungi; EDO18187; EDO18187; Kpol_543p16.
DR   GeneID; 5546461; -.
DR   KEGG; vpo:Kpol_543p16; -.
DR   eggNOG; ENOG502QQ1E; Eukaryota.
DR   HOGENOM; CLU_025632_5_1_1; -.
DR   InParanoid; A7THM1; -.
DR   OrthoDB; 719853at2759; -.
DR   PhylomeDB; A7THM1; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..446
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000351065"
FT   TOPO_DOM        ?..305
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        327..424
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        446
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   COILED          186..285
FT                   /evidence="ECO:0000255"
FT   COILED          344..390
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   446 AA;  51612 MW;  752B74D8495178ED CRC64;
     MDTLHGELVL GMMNRIVCRG NLLKSSFYSS SRIGYSSIYD TGSIRSFTST GILSNSKSKL
     TGGGNVDGNK GNNGNEDLLK GFKSKLDHSK DLFSKYKSLL VKNIDNVKEA IREANRKFAE
     QEAQAGVDSK LSYNKDVSTG GVIGGLPSER EIRRRKWSRR LEFYLDSLQE TIFSASKAFN
     DVTGYSSIQK LRKSIDLLQI QLEVMKRELK TLRVDYEESI EKRINSQRQV NELLQRKSSW
     SATDLENFTQ LYKDDATNSK REQDLKTELK NKEEAQEKIT DELYSAILTR YHEEQIWSDK
     IRRTSIWSTF MLMAVNLFLF VILQLFLEPW KRRRLVRAFE RNVRTSLEAQ AADHQLHYEQ
     LNAQLQEQSR LIQQELEMEK FKDDKRKQDE PQTPSTIWGW FLQLINKLQN LSPMDMNCQT
     NFNTLQIYLL VTSVGVISSI LTTLIS