ID   SHE9_YARLI              Reviewed;         580 AA.
AC   Q6C7F7;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=SHE9; OrderedLocusNames=YALI0E01188g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG78984.1; -; Genomic_DNA.
DR   RefSeq; XP_503405.1; XM_503405.1.
DR   AlphaFoldDB; Q6C7F7; -.
DR   SMR; Q6C7F7; -.
DR   STRING; 4952.CAG78984; -.
DR   EnsemblFungi; CAG78984; CAG78984; YALI0_E01188g.
DR   GeneID; 2912942; -.
DR   KEGG; yli:YALI0E01188g; -.
DR   VEuPathDB; FungiDB:YALI0_E01188g; -.
DR   HOGENOM; CLU_470264_0_0_1; -.
DR   InParanoid; Q6C7F7; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..20
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..580
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000351066"
FT   TOPO_DOM        21..298
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        320..557
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        558..578
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        579..580
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   REGION          45..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          177..275
FT                   /evidence="ECO:0000255"
FT   COILED          377..423
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        86..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..134
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   580 AA;  66744 MW;  D413028C4E4BDE92 CRC64;
     MLTRRMQCLR GAGVFRTVAA LPLLAQRPNF YRPLTCSALR RNNDHSYRHE SRKDKEMQDL
     KESRKMREQE ALDDAAFRNT FEFAVEKTRD SDGKSPEPEV EIDVDREAQT PWDPVGSQSR
     HETRQEHRER FDDIKKTLPS SVHESQPQMY KWFGEKMDQI QAGALTAGQT LNEVTGYKAI
     EKLKLSIEKL EDEVLEARAE VREAKRMYSD AISERSNSQR EVNELLQRKH NWTPADLERF
     TELYRNDHAN EHSVNDAKKR LGECEHHVED LTLQLSKQIL TRYHEEQIWS DKIRRASTWG
     TWILMGFNVV LFIVVQLGLE PWKRRRLVGS FEDKVKESLQ EWEARNEARR LEEATMAATA
     TQAITELQRR IESPHVSKAD VVEAEAEINS IKTNLATWFK EREEEEKEEI AKEAHELAVI
     AEDPDMTDVH HKPHPPQPVD TERVVRPHLV ENFEHHVADP VHHPTLPITS TPVLEEDAPP
     PRIHPLVQMS PDSPDDGTKT FTATRDGYDV HPLVVRPTTP PHFMLQVWGA AKLSVESATN
     KTVAVVRSTF QTAEQRPFES TIVASLGGLC GGLVTFLYLR