ID   SHEP_DROAN              Reviewed;         597 AA.
AC   B3M3R5;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Protein alan shepard;
GN   Name=shep {ECO:0000250|UniProtKB:Q8MSV2}; ORFNames=GF10470;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1] {ECO:0000312|EMBL:EDV40358.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13 {ECO:0000312|EMBL:EDV40358.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Has a role in the perception of gravity.
CC       {ECO:0000250|UniProtKB:Q8MSV2}.
CC   -!- MISCELLANEOUS: Named after Alan Bartlett Shepard, Jr. who was the
CC       second person and the first American in space and the fifth person to
CC       walk on the moon.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDV40358.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH902618; EDV40358.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001957552.2; XM_001957516.2.
DR   AlphaFoldDB; B3M3R5; -.
DR   SMR; B3M3R5; -.
DR   STRING; 7217.FBpp0113662; -.
DR   EnsemblMetazoa; FBtr0392111; FBpp0351509; FBgn0087511.
DR   eggNOG; KOG4733; Eukaryota.
DR   InParanoid; B3M3R5; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009629; P:response to gravity; ISS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..597
FT                   /note="Protein alan shepard"
FT                   /id="PRO_0000379496"
FT   DOMAIN          236..312
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          324..403
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          169..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..597
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..586
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         5
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         130
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         147
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
SQ   SEQUENCE   597 AA;  62683 MW;  7AE55D676913F759 CRC64;
     MHPRYSPAPP PQQHQGPQMG GPHPHQGGVS GGGGGGIGNM RGSGNMQQLP PQIPRSQNYS
     TGSSSSAAAA PPTPRSAFPG APLTASAVAL KGALPQRPPA MTSPAAAAAG AALAAGAPYR
     GAASWTPQGY APAAAAAAAA VAQQAAYRYT APLPQPAYAA YTPHTATTPA TTTYGQRVPT
     AASPSNTNSS SSSNTGSQSG TLSTSLSNTT NTNTNMGPNG TAQNQNQQGG EQLSKTNLYI
     RGLQQGTTDK DLVNMCAQYG TIISTKAILD KTTNKCYGFV DFEQPAFAEC AVKGLQGKGV
     QAQMAKVGIW VLHRPAIQQE QDPTNLYIAN LPPHYKETDL EAMLSKYGQV VSTRILRDQQ
     MNSKGVGFAR MESREKCEQI IQMFNGNTIP GGKDPLLVKF ADGGPKKKNL FKTPDPNARA
     WRDVSAEGIP VAYDPTLQQN GVSVNVGTPI GVPYSRFSAP QVGGYPVAGS QWIPGYMMTQ
     PITQVDDQYM QMAAAPQLGV TSYKPEAVNQ VQPRGISMMV SGDTAVPYGT MMPQLATLQI
     GNSNFSPSLQ YISPTYPYYA PPPTIIPTMP MTDSEQASTA ASPDEAYTQY PHQAAPK