ID   SHEP_DROGR              Reviewed;         609 AA.
AC   B4IX08;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Protein alan shepard;
GN   Name=shep {ECO:0000250|UniProtKB:Q8MSV2}; ORFNames=GH15273;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1] {ECO:0000312|EMBL:EDV96314.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDV96314.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Has a role in the perception of gravity.
CC       {ECO:0000250|UniProtKB:Q8MSV2}.
CC   -!- MISCELLANEOUS: Named after Alan Bartlett Shepard, Jr. who was the
CC       second person and the first American in space and the fifth person to
CC       walk on the moon.
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DR   EMBL; CH916366; EDV96314.1; -; Genomic_DNA.
DR   RefSeq; XP_001983966.1; XM_001983930.1.
DR   AlphaFoldDB; B4IX08; -.
DR   SMR; B4IX08; -.
DR   STRING; 7222.FBpp0149179; -.
DR   EnsemblMetazoa; FBtr0150687; FBpp0149179; FBgn0122748.
DR   GeneID; 6558604; -.
DR   eggNOG; KOG4733; Eukaryota.
DR   HOGENOM; CLU_016278_1_1_1; -.
DR   InParanoid; B4IX08; -.
DR   OMA; HTMPLGD; -.
DR   PhylomeDB; B4IX08; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009629; P:response to gravity; ISS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..609
FT                   /note="Protein alan shepard"
FT                   /id="PRO_0000379498"
FT   DOMAIN          257..330
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          336..415
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..91
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        583..598
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         5
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         152
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         168
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
SQ   SEQUENCE   609 AA;  63822 MW;  37A846FA923031FA CRC64;
     MHPRYSPAPP PLHQQQQQQP PQQQQQQMGG PHQQQSGGVG PGTGHGGVGA AVGASNAGHM
     RAPPNSQQLP PPMPRSQNYA NGSSSAASVA AAPPTPRSAF PGAPLTASAV ALKGAIPQRP
     PAMTSPAAAA AGAALAAGAP YRGATSWTPQ GYAPAAAAAA AAVAQQAYRY TAPLPQPAYA
     AYTPHTATTP ATTTYGQRVP TAASPSNTNS SSSSNTGSQS GTLSTSLSNT TNTNTTMGPN
     GTAQNQNQQG GEQLSKTNLY IRGLQQGTTD KDLINMCAQY GTIISTKAIL DKTTNKCKGY
     GFVDFEQPAY AEGAVKGLQA KGVQAQMAKQ QEQDPTNLYI ANLPPHFKET DLEAMLAKYG
     QVVSTRILRD QQMNSKGVGF ARMESREKCE QIIQMFNGNT IPGAKDPLLV KFADGGPKKK
     NLFKTPDPSA RAWRDVSAEG IPVAYDPSMQ QNGVSVNVGT PIGVPYSRFG APQVGGYPVA
     GSQWIPGYMM TQPITQVDDQ YSSSALQYMQ MAAAPQLGVT SYKPEAVNQV QPRGISMMVS
     GDTAVPYGTM MPQLATLQIG NSYISPTYPY YAPPPTIIPT MPMTDSEQAS TAASPDEAYT
     QYPHQAAPK