ID   SHEP_DROMO              Reviewed;         592 AA.
AC   B4KX02;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Protein alan shepard;
GN   Name=shep {ECO:0000250|UniProtKB:Q8MSV2}; ORFNames=GI11982;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1] {ECO:0000312|EMBL:EDW18623.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000312|EMBL:EDW18623.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Has a role in the perception of gravity.
CC       {ECO:0000250|UniProtKB:Q8MSV2}.
CC   -!- MISCELLANEOUS: Named after Alan Bartlett Shepard, Jr. who was the
CC       second person and the first American in space and the fifth person to
CC       walk on the moon.
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DR   EMBL; CH933809; EDW18623.1; -; Genomic_DNA.
DR   RefSeq; XP_002008147.2; XM_002008111.2.
DR   AlphaFoldDB; B4KX02; -.
DR   SMR; B4KX02; -.
DR   STRING; 7230.FBpp0161199; -.
DR   PRIDE; B4KX02; -.
DR   eggNOG; KOG4733; Eukaryota.
DR   HOGENOM; CLU_016278_1_0_1; -.
DR   InParanoid; B4KX02; -.
DR   OMA; HTMPLGD; -.
DR   PhylomeDB; B4KX02; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009629; P:response to gravity; ISS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..592
FT                   /note="Protein alan shepard"
FT                   /id="PRO_0000379500"
FT   DOMAIN          229..307
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          319..398
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          162..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          565..592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        565..581
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         124
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         140
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
SQ   SEQUENCE   592 AA;  62304 MW;  4C916D5D19492EE3 CRC64;
     MGGPHHQHQQ HQQQQQVVGG GNGHGGGAPV HMRAPPNSQQ LPPQMPRSQN YANGSSSAAS
     VAAAPPTPRS AFPGAPLTAS AVALKGAIPQ RPPAMTSPAA AAAGAALAAG APYRGATSWT
     PQGYAPAAAA AAAAVAQQAY RYTAPLPQPA YAAYTPHTAT TPATTTYGQR VPTAASPSNT
     NSSSSSNTGS QSGTLSTSLS NTTNTNTTMG PNGTAQNQNQ QGGEQLSKTN LYIRGLQQGT
     TDKDLINMCA QYGTIISTKA ILDKTTNKCK GYGFVDFEQP AYAEGAVKGL QAKGVQAQMA
     KVGIWVLHRP AIQQEQDPTN LYIANLPPHF KETDLEAMLA KFGQVVSTRI LRDQQMNSKG
     VGFARMESRE KCEQIIQMFN GNTITGAKDP LLVKFADGGP KKKNLFKTPD PNARAWRDVS
     AEGIPVAYDP TMQQNGVSVN VGTPIGVPYS RFGAPQVGGY PVAGSQWIPG YMMTQPITQV
     DDQYSSSALQ YMQMAAAPQL GVTSYKPQEV NQVPARGISM MVSGDTAVPY GTMMPQLATL
     QIGNSYISPT YPYYAPPPTI LPTMPMTDSE QASTAASPDE AYTQYPHQAA PK