ID   SHEP_DROSE              Reviewed;         579 AA.
AC   B4HUE4;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Protein alan shepard;
GN   Name=shep {ECO:0000250|UniProtKB:Q8MSV2}; ORFNames=GM13927;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1] {ECO:0000312|EMBL:EDW50565.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25 {ECO:0000312|EMBL:EDW50565.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Has a role in the perception of gravity.
CC       {ECO:0000250|UniProtKB:Q8MSV2}.
CC   -!- MISCELLANEOUS: Named after Alan Bartlett Shepard, Jr. who was the
CC       second person and the first American in space and the fifth person to
CC       walk on the moon.
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DR   EMBL; CH480817; EDW50565.1; -; Genomic_DNA.
DR   RefSeq; XP_002035429.1; XM_002035393.1.
DR   AlphaFoldDB; B4HUE4; -.
DR   SMR; B4HUE4; -.
DR   STRING; 7238.B4HUE4; -.
DR   EnsemblMetazoa; FBtr0196912; FBpp0195404; FBgn0168857.
DR   GeneID; 6610863; -.
DR   KEGG; dse:6610863; -.
DR   HOGENOM; CLU_016278_1_0_1; -.
DR   OMA; HTMPLGD; -.
DR   PhylomeDB; B4HUE4; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008344; P:adult locomotory behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0008050; P:female courtship behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0042332; P:gravitaxis; IEA:EnsemblMetazoa.
DR   GO; GO:0007552; P:metamorphosis; IEA:EnsemblMetazoa.
DR   GO; GO:0016322; P:neuron remodeling; IEA:EnsemblMetazoa.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:EnsemblMetazoa.
DR   GO; GO:0009629; P:response to gravity; ISS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..579
FT                   /note="Protein alan shepard"
FT                   /id="PRO_0000379501"
FT   DOMAIN          231..304
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          310..389
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          164..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          553..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        553..568
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         5
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         125
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         142
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
SQ   SEQUENCE   579 AA;  60779 MW;  83B39261A2F04E10 CRC64;
     MHPRYSPAPP PQQQQQMGGP PHQQQGGGGG GGGSMRGPSN AQQLPPQIPR SQNYSNGSSS
     SAAAAPLTSR SAFPGAPLTA SAVALKGALP QRPPAMTSPA AAAAGAALAA GAPYRGAASW
     TPQGYAPAAA AAAAAVAQQA AYRYTAPLPQ PAYAAYTPHT ATTPATTTYG QRVPTAASPS
     NTNSSSSSNT GSQSGTLSTS LSNTTNTNTN MGPNGTVQNQ NQQGGEQLSK TNLYIRGLQQ
     GTTDKDLVNM CAQYGTIIST KAILDKTTNK CKGYGFVDFE QPAFAECAVK GLQGKGVQAQ
     MAKQQEQDPT NLYIANLPPH FKETDLEAML SKYGQVVSTR ILRDQQMNSK GVGFARMESR
     EKCEQIIQMF NGNTIPGAKD PLLVKFADGG PKKKNLFKTP DPNARAWRDV SAEGIPVAYD
     PTMQQNGVSV NVGTPIGVPY SRFSAPQVGG YPVAGSQWIP GYMMTTQVDD QTSYSPQYMQ
     MAAAPQLGVT SYKPEAVNQV QPRGISMMVS GDTGVPYGTM MPQLATLQIG NSYISPTYPY
     YAPPPTIIPT MPMTDSEQAS TAASPDEAYT QYPHQAAPK