ID   SHEP_DROSI              Reviewed;         576 AA.
AC   B4QRJ0;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Protein alan shepard;
GN   Name=shep {ECO:0000250|UniProtKB:Q8MSV2}; ORFNames=GD13207;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1] {ECO:0000312|EMBL:EDX09301.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Has a role in the perception of gravity.
CC       {ECO:0000250|UniProtKB:Q8MSV2}.
CC   -!- MISCELLANEOUS: Named after Alan Bartlett Shepard, Jr. who was the
CC       second person and the first American in space and the fifth person to
CC       walk on the moon.
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DR   EMBL; CM000363; EDX09301.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4QRJ0; -.
DR   SMR; B4QRJ0; -.
DR   STRING; 7240.B4QRJ0; -.
DR   HOGENOM; CLU_016278_1_0_1; -.
DR   OMA; HTMPLGD; -.
DR   PhylomeDB; B4QRJ0; -.
DR   Proteomes; UP000000304; Chromosome 3l.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009629; P:response to gravity; ISS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..576
FT                   /note="Protein alan shepard"
FT                   /id="PRO_0000379502"
FT   DOMAIN          231..302
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          308..387
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          164..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          538..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        548..565
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         5
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         125
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         142
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
SQ   SEQUENCE   576 AA;  60463 MW;  53B2272923AA8BC9 CRC64;
     MHPRYSPAPP PQQQQQMGGP PHQQQGGGGG GGGNMRGPSN AQQLPPQIPR SQNYSNGSSS
     SAAAAPLTSR SAFPGAPLTA SAVALKGALP QRPPAMTSPA AAAAGAALAA GAPYRGAASW
     TPQGYAPAAA AAAAAVAQQA AYRYTAPLPQ PAYAAYTPHT ATTPATTTYG QRVPTAASPS
     NTNSSSSSNT GSQSGTLSTS LSNTTNTNTN MGPNGTVQNQ NQQGGEQLSK TNLYIRGLQQ
     GTTDKDLVNM CAQYGTIIST KAILDKTTNK CYGFVDFEQP AFAECAVKGL QGKGVQAQMA
     KQQEQDPTNL YIANLPPHFK ETDLEAMLSK YGQVVSTRIL RDQQMNSKGV GFARMESREK
     CEQIIQMFNG NTIPGAKDPL LVKFADGGPK KKNLFKTPDP NARAWRDVSA EGIPVAYDPT
     MQQNGVSVNV GTPIGVPYSR FSAPQVGGYP VAGSQWIPGY MMTTQVDDQT SYSPQYMQMA
     AAPQLGVTSY KPEAVNQVQP RGISMMVSGD TGVPYGTMMP QLATLQIGNS VSHRSPYYAP
     PPTIIPTMPM TDSEQASTAA SPDEAYTQYP HQAAPK