ID   SHEP_DROVI              Reviewed;         595 AA.
AC   B4LFQ9;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Protein alan shepard;
GN   Name=shep {ECO:0000250|UniProtKB:Q8MSV2}; ORFNames=GJ12205;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000312|EMBL:EDW69286.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000312|EMBL:EDW69286.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Has a role in the perception of gravity.
CC       {ECO:0000250|UniProtKB:Q8MSV2}.
CC   -!- MISCELLANEOUS: Named after Alan Bartlett Shepard, Jr. who was the
CC       second person and the first American in space and the fifth person to
CC       walk on the moon.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDW69286.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH940647; EDW69286.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002046944.2; XM_002046908.2.
DR   AlphaFoldDB; B4LFQ9; -.
DR   SMR; B4LFQ9; -.
DR   STRING; 7244.FBpp0226622; -.
DR   EnsemblMetazoa; FBtr0436529; FBpp0393420; FBgn0199455.
DR   eggNOG; KOG4733; Eukaryota.
DR   InParanoid; B4LFQ9; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009629; P:response to gravity; ISS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..595
FT                   /note="Protein alan shepard"
FT                   /id="PRO_0000379503"
FT   DOMAIN          243..316
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          322..401
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          569..595
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         5
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         138
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         154
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
SQ   SEQUENCE   595 AA;  62562 MW;  4F797ED4D9B00B99 CRC64;
     MHPRYSPAPP PHQQQQQQQQ QPMGGPHQQQ SAGGGPGHGG GASGHMRAPP NSQQLPPQMP
     RSQNYANGSS SAASVAAAPP TPRSAFPGAP LTASAVALKG AIPQRPPAMT SPAAAAAGAA
     LAAGAPYRGA TSWTPQGYAP AAAAAAAAVA QQAYRYTAPL PQPAYAAYTP HTATTQATTT
     YGQRVPTAAS PSNTNSSSSS NTGSQSGTLS TSLSNTTNTN TTMGPNGTAQ NQNQQGGEQL
     SKTNLYIRGL QQGTTDKDLI NMCAQYGTII STKAILDKTT NKCKGYGFVD FEQPAYAEGA
     VKGLQAKGVQ AQMAKQQEQD PTNLYIANLP PHFKETDLEA MLAKYGQVVS TRILRDQQMN
     SKGVGFARME SREKCEQIIQ MFNGNTIPGA KDPLLVKFAD GGPKKKNLFK TPDPNARAWR
     DVSAEGIPVA YDPTMQQNGV SVNVGTPIGV PYSRFGAPQV GGYPVAGSQW IPGYMMTQPI
     TQVDDQYSSS ALQYMQMAAA PQLGVTSYKP EAVNQVQPRG ISMMVSGDTA VPYGTMMPQL
     ATLQIGNSYI SPTYPYYAPP PTIIPTMPMT DSEQASTAAS PDEAYTQYPH QAAPK