ID   SHEP_DROWI              Reviewed;         581 AA.
AC   B4MM23;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Protein alan shepard;
GN   Name=shep {ECO:0000250|UniProtKB:Q8MSV2}; ORFNames=GK17327;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1] {ECO:0000312|EMBL:EDW73032.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000312|EMBL:EDW73032.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Has a role in the perception of gravity.
CC       {ECO:0000250|UniProtKB:Q8MSV2}.
CC   -!- MISCELLANEOUS: Named after Alan Bartlett Shepard, Jr. who was the
CC       second person and the first American in space and the fifth person to
CC       walk on the moon.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDW73032.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH963847; EDW73032.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002062046.2; XM_002062010.2.
DR   AlphaFoldDB; B4MM23; -.
DR   SMR; B4MM23; -.
DR   STRING; 7260.FBpp0246470; -.
DR   eggNOG; KOG4733; Eukaryota.
DR   InParanoid; B4MM23; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009629; P:response to gravity; ISS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..581
FT                   /note="Protein alan shepard"
FT                   /id="PRO_0000379504"
FT   DOMAIN          237..310
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          316..395
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          168..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..581
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        555..570
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         5
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         128
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT   MOD_RES         146
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8MSV2"
SQ   SEQUENCE   581 AA;  61124 MW;  907785CDC82C7E19 CRC64;
     MHPRYSPAPP LQQQQQQHQQ MTGIGGPGGL LRGPANNSQQ LPPQMPRSQN YANGSSSSAA
     AASAVTAAPP TPRSAFPVAP LTASAVALKG AIPQRPPAMT SPAAAAAGAA LAAGAPYRGA
     TSWTPQGYAP AAAAAAAAVA QQAAAYRYTA PLPQPAYAAY TPHTATTPAT TTYGQRVPTA
     ASPSNTNSSS SSNTGSQSGT LSTSLSHTTN TNTNMGPNGT AQNQNQQGGG GEQLSKTNLY
     IRGLQQGTTD KDLVNMCAQY GTIISTKAIL DKTTNKCKGY GFVDFEQPAY AENAVKGLQA
     KGVQAQMAKQ QEQDPTNLYI ANLPPHFKET DLEAMLSKYG QVVSTRILRD QQMNSKGVGF
     ARMESREKCE QIIQMFNGNT IPGAKDPLLV KFADGGPKKK NLFKTPDPNT RAWRDVSAEG
     IPVAYDPTLQ QNGVSVNVGT PIGVPYSRFS APPVGGYPVA GSQWIPGYMM TQPITQVDDQ
     YMQMAAPQLG VTSYKPEAVN QVQPRGISMM VSGDTGVPYG TMMPQLATLQ IGNSYISPTY
     PYYAPPPTII PTMPMTDSEQ ASTAASPDEA YTQYPHQAAP K