SHEP_DROYA
ID SHEP_DROYA Reviewed; 582 AA.
AC B4PIS2;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Protein alan shepard;
GN Name=shep {ECO:0000250|UniProtKB:Q8MSV2}; ORFNames=GE20568;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1] {ECO:0000312|EMBL:EDW93492.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000312|EMBL:EDW93492.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Has a role in the perception of gravity.
CC {ECO:0000250|UniProtKB:Q8MSV2}.
CC -!- MISCELLANEOUS: Named after Alan Bartlett Shepard, Jr. who was the
CC second person and the first American in space and the fifth person to
CC walk on the moon.
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DR EMBL; CM000159; EDW93492.1; -; Genomic_DNA.
DR RefSeq; XP_002093780.1; XM_002093744.2.
DR AlphaFoldDB; B4PIS2; -.
DR SMR; B4PIS2; -.
DR STRING; 7245.FBpp0265578; -.
DR EnsemblMetazoa; FBtr0267086; FBpp0265578; FBgn0237877.
DR GeneID; 6533045; -.
DR KEGG; dya:Dyak_GE20568; -.
DR eggNOG; KOG4733; Eukaryota.
DR HOGENOM; CLU_016278_1_0_1; -.
DR OMA; HTMPLGD; -.
DR PhylomeDB; B4PIS2; -.
DR Proteomes; UP000002282; Chromosome 3L.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009629; P:response to gravity; ISS:UniProtKB.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR002343; Hud_Sxl_RNA.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR PRINTS; PR00961; HUDSXLRNA.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Phosphoprotein; Repeat; RNA-binding.
FT CHAIN 1..582
FT /note="Protein alan shepard"
FT /id="PRO_0000379505"
FT DOMAIN 231..304
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 310..389
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 5
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT MOD_RES 125
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q8MSV2"
FT MOD_RES 142
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q8MSV2"
SQ SEQUENCE 582 AA; 61069 MW; 04BE37E43030AA78 CRC64;
MHPRYSPAPP PQQQQQMGGP LHQQQGGGGG GGGGIRGPSN AQQLPPQIPR SQNYSNGSSS
SAAAAPPTSR SAFPGAPLTA SAVALKGALP QRPPAMTSPA AAAAGAALAA GAPYRGAASW
TPQGYAPAAA AAAAAVAQQA AYRYTAPLPQ PAYAAYTPHT ATTPATTTYG QRVPTAASPS
NTNSSSSSNT GSQSGTLSTS LSNTTNTNTN MGPNGTVQNQ NQQGGEQLSK TNLYIRGLQQ
GTTDKDLVNM CAQYGTIIST KAILDKTTNK CKGYGFVDFE QPAFAECAVK GLQGKGVQAQ
MAKQQEQDPT NLYIANLPPH FKETDLEAML SKYGQVVSTR ILRDQQMNSK GVGFARMESR
EKCEQIIQMF NGNTIPGAKD PLLVKFADGG PKKKNLFKTP DPNARAWRDV SAEGIPVAYD
PTMQQNGVSV NVGTPIGVPY SRFSAPQVGG YPVAGSQWIP GYMMTQPITQ VDDQTSYSPQ
YMQMAAAPQL GVTSYKPEAV NQVQPRGISM MVSGDTGVPY GTMMPQLATL QIGNSYISPT
YPYYAPPPTI IPTMPMTDSE QASTAASPDE AYTQYPHQAA PK
