SHE_HUMAN
ID SHE_HUMAN Reviewed; 495 AA.
AC Q5VZ18; Q8TEQ5;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=SH2 domain-containing adapter protein E;
GN Name=SHE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 187-495.
RC TISSUE=Spleen;
RX PubMed=12693554; DOI=10.1093/dnares/10.1.49;
RA Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N.,
RA Ohara O.;
RT "Characterization of long cDNA clones from human adult spleen. II. The
RT complete sequences of 81 cDNA clones.";
RL DNA Res. 10:49-57(2003).
CC -!- INTERACTION:
CC Q5VZ18; P10275: AR; NbExp=3; IntAct=EBI-3956977, EBI-608057;
CC Q5VZ18; Q13643: FHL3; NbExp=3; IntAct=EBI-3956977, EBI-741101;
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DR EMBL; AL162591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117210; AAI17211.1; -; mRNA.
DR EMBL; AK074067; BAB84893.1; -; mRNA.
DR CCDS; CCDS30877.1; -.
DR RefSeq; NP_001010846.1; NM_001010846.2.
DR RefSeq; XP_011507465.1; XM_011509163.2.
DR AlphaFoldDB; Q5VZ18; -.
DR SMR; Q5VZ18; -.
DR BioGRID; 126009; 7.
DR IntAct; Q5VZ18; 5.
DR STRING; 9606.ENSP00000307369; -.
DR iPTMnet; Q5VZ18; -.
DR PhosphoSitePlus; Q5VZ18; -.
DR BioMuta; SHE; -.
DR DMDM; 74747744; -.
DR jPOST; Q5VZ18; -.
DR MassIVE; Q5VZ18; -.
DR PaxDb; Q5VZ18; -.
DR PeptideAtlas; Q5VZ18; -.
DR PRIDE; Q5VZ18; -.
DR ProteomicsDB; 65663; -.
DR Antibodypedia; 51057; 48 antibodies from 15 providers.
DR DNASU; 126669; -.
DR Ensembl; ENST00000304760.3; ENSP00000307369.2; ENSG00000169291.10.
DR GeneID; 126669; -.
DR KEGG; hsa:126669; -.
DR MANE-Select; ENST00000304760.3; ENSP00000307369.2; NM_001010846.3; NP_001010846.1.
DR UCSC; uc001ffb.4; human.
DR CTD; 126669; -.
DR GeneCards; SHE; -.
DR HGNC; HGNC:27004; SHE.
DR HPA; ENSG00000169291; Low tissue specificity.
DR MIM; 610482; gene.
DR neXtProt; NX_Q5VZ18; -.
DR OpenTargets; ENSG00000169291; -.
DR PharmGKB; PA142670919; -.
DR VEuPathDB; HostDB:ENSG00000169291; -.
DR eggNOG; ENOG502R9PR; Eukaryota.
DR GeneTree; ENSGT00940000159107; -.
DR HOGENOM; CLU_029444_5_0_1; -.
DR InParanoid; Q5VZ18; -.
DR OMA; RLQPCRE; -.
DR OrthoDB; 1120795at2759; -.
DR PhylomeDB; Q5VZ18; -.
DR TreeFam; TF325799; -.
DR PathwayCommons; Q5VZ18; -.
DR SignaLink; Q5VZ18; -.
DR BioGRID-ORCS; 126669; 19 hits in 1059 CRISPR screens.
DR ChiTaRS; SHE; human.
DR GenomeRNAi; 126669; -.
DR Pharos; Q5VZ18; Tdark.
DR PRO; PR:Q5VZ18; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VZ18; protein.
DR Bgee; ENSG00000169291; Expressed in cardiac muscle of right atrium and 169 other tissues.
DR ExpressionAtlas; Q5VZ18; baseline and differential.
DR Genevisible; Q5VZ18; HS.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IBA:GO_Central.
DR CDD; cd10391; SH2_SHE; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035041; SHE.
DR InterPro; IPR035042; SHE_SH2.
DR PANTHER; PTHR15127:SF29; PTHR15127:SF29; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; SH2 domain.
FT CHAIN 1..495
FT /note="SH2 domain-containing adapter protein E"
FT /id="PRO_0000246775"
FT DOMAIN 395..490
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 51..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 107
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BSD5"
SQ SEQUENCE 495 AA; 53950 MW; 7E1E3D9645B00536 CRC64;
MQWSPTPGAS ACLGWASSLA CSTAPTLLGR AGRGPLMAAK WFKEFPLNLK TVSERAKPGG
GGGKLRKNSE AGGAGPGPGK GRKNSAAELG SGRAGVGPKD SRLSRDSLQG LIQAAAGKGR
KNSRATEEEP HRGATKSSGC STYINRLIKV DTQEKNGKSN YPSSSSSSSS SSSSASSSPS
SLGPELDKGK IIKQQETVII LEDYADPYDA KRTKGQRDAE RVGENDGYME PYDAQQMITE
IRRRGSKDPL VKALQLLDSP CEPADGGLKS ETLAKRRSSK DLLGKPPQLY DTPYEPAEGG
PRAEGKARPP DSRLPENDER PAAEYEQPWE WKKEQIVRAL SVQFEGAERP SFREETVRQH
HRQKSWTQKI LKPALSDHSE GEKVDPGLPL EKQPWYHGAI SRAEAESRLQ PCKEAGYLVR
NSESGNSRYS IALKTSQGCV HIIVAQTKDN KYTLNQTSAV FDSIPEVVHY YSNEKLPFKG
AEHMTLLYPV HSKLH
