SHE_MOUSE
ID SHE_MOUSE Reviewed; 492 AA.
AC Q8BSD5; Q3TZT0;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=SH2 domain-containing adapter protein E;
GN Name=She;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Embryo, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=9315092; DOI=10.1038/sj.onc.1201299;
RA Oda T., Kujovich J., Reis M., Newman B., Druker B.J.;
RT "Identification and characterization of two novel SH2 domain-containing
RT proteins from a yeast two hybrid screen with the ABL tyrosine kinase.";
RL Oncogene 15:1255-1262(1997).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Expressed in heart, brain, lung and skeletal
CC muscle. {ECO:0000269|PubMed:9315092}.
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DR EMBL; AK034662; BAC28787.1; -; mRNA.
DR EMBL; AK157580; BAE34127.1; -; mRNA.
DR EMBL; BC109363; AAI09364.1; -; mRNA.
DR CCDS; CCDS17518.1; -.
DR RefSeq; NP_766118.3; NM_172530.3.
DR AlphaFoldDB; Q8BSD5; -.
DR SMR; Q8BSD5; -.
DR STRING; 10090.ENSMUSP00000059658; -.
DR iPTMnet; Q8BSD5; -.
DR PhosphoSitePlus; Q8BSD5; -.
DR MaxQB; Q8BSD5; -.
DR PaxDb; Q8BSD5; -.
DR PeptideAtlas; Q8BSD5; -.
DR PRIDE; Q8BSD5; -.
DR ProteomicsDB; 261351; -.
DR Antibodypedia; 51057; 48 antibodies from 15 providers.
DR Ensembl; ENSMUST00000050401; ENSMUSP00000059658; ENSMUSG00000046280.
DR GeneID; 214547; -.
DR KEGG; mmu:214547; -.
DR UCSC; uc008qae.2; mouse.
DR CTD; 126669; -.
DR MGI; MGI:1099462; She.
DR VEuPathDB; HostDB:ENSMUSG00000046280; -.
DR eggNOG; ENOG502R9PR; Eukaryota.
DR GeneTree; ENSGT00940000159107; -.
DR HOGENOM; CLU_029444_5_0_1; -.
DR InParanoid; Q8BSD5; -.
DR OMA; RLQPCRE; -.
DR OrthoDB; 1120795at2759; -.
DR PhylomeDB; Q8BSD5; -.
DR TreeFam; TF325799; -.
DR BioGRID-ORCS; 214547; 7 hits in 71 CRISPR screens.
DR PRO; PR:Q8BSD5; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BSD5; protein.
DR Bgee; ENSMUSG00000046280; Expressed in brain blood vessel and 198 other tissues.
DR Genevisible; Q8BSD5; MM.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IBA:GO_Central.
DR CDD; cd10391; SH2_SHE; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035041; SHE.
DR InterPro; IPR035042; SHE_SH2.
DR PANTHER; PTHR15127:SF29; PTHR15127:SF29; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; SH2 domain.
FT CHAIN 1..492
FT /note="SH2 domain-containing adapter protein E"
FT /id="PRO_0000246776"
FT DOMAIN 393..488
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 46..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 103
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 57
FT /note="G -> C (in Ref. 1; BAE34127)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 492 AA; 53353 MW; B96EC71F1DDECF7A CRC64;
MRRPPAPGAP RCLSWASSLF CSAASTLPGP LMAAKWFKEF PLTLKTASER ARPGGAGGKP
RKNSETGGAA PTPGKGRKNS AAELGASKAS SGPPKDSRLS RDSLQGLIQA AAGKGRKNSR
VTATATEEEP HRGAVTKSAG CSTYISRLIK VDTQEKNGKS AYPGGGSTSS SSSSSSSASS
SPSSLGPELD KAKIMRQQDT VIILEDYADP YDAKRTKGQR DAERVGENDG YMEPYDAQQM
ITEIRRRGSK DPLVKALQLL DGPSEPGETV KVEATAKRRS SKDLLGKPPQ LYDTPYEPSE
GGQRVAEVKT RPADSRLPEE DDRPAAEYEQ PWEWKREQIA RALSVQFEGS DRPPGREDAG
RPHHWQKTLK PTLSDHGDGE KVDPGLALEK QPWYHGSISR AEAESRLQPC KEAAYLVRNS
ESGNSKYSIA LKTSQGCVHI IVAQTKDNKY TLNQTSAVFD SIPEVVHYYS NAKLPFKGAE
HMTLLHPVHK LH
