ID   SHFL_DANRE              Reviewed;         327 AA.
AC   A7YY07;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog {ECO:0000305};
DE            Short=SHFL;
DE   AltName: Full=Repressor of yield of DENV protein homolog;
GN   Name=shfl; ORFNames=zgc:171711;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Gill;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a
CC       variety of mRNAs from viruses and cellular genes. Interacts with the
CC       -1PRF signal of target mRNA and translating ribosomes and causes
CC       premature translation termination at the frameshifting site. May
CC       exhibit antiviral activity. {ECO:0000250|UniProtKB:Q9NUL5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NUL5}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9NUL5}. Cytoplasm, P-body
CC       {ECO:0000250|UniProtKB:Q9NUL5}. Note=Predominantly found in t for
CC       dsDNA. {ECO:0000250|UniProtKB:Q9NUL5}.
CC   -!- SIMILARITY: Belongs to the SHFL family. {ECO:0000305}.
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DR   EMBL; BC148174; AAI48175.1; -; mRNA.
DR   RefSeq; NP_001098997.1; NM_001105527.1.
DR   AlphaFoldDB; A7YY07; -.
DR   STRING; 7955.ENSDARP00000068467; -.
DR   PaxDb; A7YY07; -.
DR   GeneID; 797287; -.
DR   KEGG; dre:797287; -.
DR   CTD; 55337; -.
DR   ZFIN; ZDB-GENE-070928-25; shfl.
DR   eggNOG; ENOG502QVND; Eukaryota.
DR   InParanoid; A7YY07; -.
DR   OrthoDB; 1485595at2759; -.
DR   PhylomeDB; A7YY07; -.
DR   PRO; PR:A7YY07; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:2001125; P:negative regulation of translational frameshifting; ISS:UniProtKB.
DR   GO; GO:0006449; P:regulation of translational termination; ISS:UniProtKB.
DR   GO; GO:0035456; P:response to interferon-beta; ISS:UniProtKB.
DR   GO; GO:0075523; P:viral translational frameshifting; ISS:UniProtKB.
DR   InterPro; IPR026795; SHFL.
DR   PANTHER; PTHR16135; PTHR16135; 1.
DR   Pfam; PF15135; UPF0515; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..327
FT                   /note="Shiftless antiviral inhibitor of ribosomal
FT                   frameshifting protein homolog"
FT                   /id="PRO_0000318704"
FT   REGION          82..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           163..179
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NUL5"
FT   MOTIF           304..312
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NUL5"
FT   COMPBIAS        91..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  37546 MW;  DA4976FD1AA24E80 CRC64;
     MSRMHEEVEL EKSVRRLREK FHGLIEIDTA VLLMRRYVKN HRMVAMWIAL MADNDRELDE
     EDQAALNNDP VAKNVIMKLK AEEQQQEEKH AKSSSSGSSG AGPSAKAKKQ PSDDRDITEL
     GTRLRVLPLT MENKRMFDQA QANQIPSDTH QFACESCDRD WWRRVPQRKR VSRCHRCKKK
     NDPVPPDRMW GIAEFTCPNC TRNFKGFGRM DGRSPCYGCR SAIYPMKILP PRRKNMMPGP
     KQRNQHSCFA EDCYHRMEPH VPGTECVHPH SRQKNRKPRV VYPSPAHISS GSTVNTCLSQ
     GSLIESINEL ILDDIEEESE DDSDSSS