ID   SHFL_XENLA              Reviewed;         305 AA.
AC   Q6GMD3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog {ECO:0000305};
DE            Short=SHFL;
DE   AltName: Full=Repressor of yield of DENV protein homolog;
GN   Name=shfl;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a
CC       variety of mRNAs from viruses and cellular genes. Interacts with the
CC       -1PRF signal of target mRNA and translating ribosomes and causes
CC       premature translation termination at the frameshifting site. May
CC       exhibit antiviral activity. {ECO:0000250|UniProtKB:Q9NUL5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NUL5}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9NUL5}. Cytoplasm, P-body
CC       {ECO:0000250|UniProtKB:Q9NUL5}. Note=Predominantly found in t for
CC       dsDNA. {ECO:0000250|UniProtKB:Q9NUL5}.
CC   -!- SIMILARITY: Belongs to the SHFL family. {ECO:0000305}.
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DR   EMBL; BC074135; AAH74135.1; -; mRNA.
DR   RefSeq; NP_001086054.1; NM_001092585.1.
DR   RefSeq; XP_018106459.1; XM_018250970.1.
DR   AlphaFoldDB; Q6GMD3; -.
DR   PRIDE; Q6GMD3; -.
DR   GeneID; 444483; -.
DR   KEGG; xla:444483; -.
DR   CTD; 444483; -.
DR   Xenbase; XB-GENE-951928; shfl.L.
DR   OMA; CRKCKVK; -.
DR   OrthoDB; 1485595at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 444483; Expressed in liver and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; ISS:UniProtKB.
DR   GO; GO:2001125; P:negative regulation of translational frameshifting; ISS:UniProtKB.
DR   GO; GO:0006449; P:regulation of translational termination; ISS:UniProtKB.
DR   GO; GO:0035456; P:response to interferon-beta; ISS:UniProtKB.
DR   GO; GO:0075523; P:viral translational frameshifting; ISS:UniProtKB.
DR   InterPro; IPR026795; SHFL.
DR   PANTHER; PTHR16135; PTHR16135; 1.
DR   Pfam; PF15135; UPF0515; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..305
FT                   /note="Shiftless antiviral inhibitor of ribosomal
FT                   frameshifting protein homolog"
FT                   /id="PRO_0000318705"
FT   MOTIF           141..157
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NUL5"
FT   MOTIF           279..288
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NUL5"
SQ   SEQUENCE   305 AA;  35687 MW;  641C7F425EB8880A CRC64;
     MMEGNVQEEL ELEKSVRRFR EKFHGKVALE TAVVLMRRFA NNHNQVCTYV ILYMDNDTDL
     DVRNHLRNDQ VAMNVINKIK RDDQRAKEMP KDKDIQDLAK KMNTLPLTQK NLKMFNDAAE
     NRIPARDRQF ACKECDYMWW RRVPQRKEVS RCQRCRKKFD PVPDNKMWGI GEYNCQSCKR
     MFRGYGQIEV SSPCYMCSKP VSPSCILPPR RNQGPRTRNT HSCFAEYCYN RKEPFVPGLQ
     CAHPKSRILN QLPKVLHPSE WHISTGSTIA TCLSQGSLNE NDIDDIILDD IKEEEDDEET
     DDSDS