SHKB1_BOVIN
ID SHKB1_BOVIN Reviewed; 704 AA.
AC A3KMV1;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=SH3KBP1-binding protein 1;
GN Name=SHKBP1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR
CC signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents
CC its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR
CC containing vesicles upon EGF stimulation.
CC {ECO:0000250|UniProtKB:Q6P7W2}.
CC -!- SUBUNIT: Monomer. Interacts with CUL3; interaction is direct and forms
CC a 5:5 heterodecamer (By similarity). Interacts (via PXXXPR motifs) with
CC SH3KBP1 (via SH3 domains) (By similarity). Directly interacts with
CC cathepsin B/CTSB (By similarity). {ECO:0000250|UniProtKB:Q6P7W2,
CC ECO:0000250|UniProtKB:Q8TBC3}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q8TBC3}.
CC -!- SIMILARITY: Belongs to the KCTD3 family. {ECO:0000305}.
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DR EMBL; BC133279; AAI33280.1; -; mRNA.
DR RefSeq; NP_001076076.1; NM_001082607.1.
DR AlphaFoldDB; A3KMV1; -.
DR SMR; A3KMV1; -.
DR STRING; 9913.ENSBTAP00000006241; -.
DR PaxDb; A3KMV1; -.
DR PRIDE; A3KMV1; -.
DR Ensembl; ENSBTAT00000006241; ENSBTAP00000006241; ENSBTAG00000004755.
DR GeneID; 512402; -.
DR KEGG; bta:512402; -.
DR CTD; 92799; -.
DR VEuPathDB; HostDB:ENSBTAG00000004755; -.
DR VGNC; VGNC:34602; SHKBP1.
DR eggNOG; KOG2714; Eukaryota.
DR GeneTree; ENSGT00940000153881; -.
DR HOGENOM; CLU_012214_0_1_1; -.
DR InParanoid; A3KMV1; -.
DR OMA; NWLEIAY; -.
DR OrthoDB; 351369at2759; -.
DR TreeFam; TF313754; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000004755; Expressed in blood and 105 other tissues.
DR ExpressionAtlas; A3KMV1; baseline.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Lysosome; Phosphoprotein; Reference proteome; Repeat;
KW WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8TBC3"
FT CHAIN 2..704
FT /note="SH3KBP1-binding protein 1"
FT /id="PRO_0000307931"
FT DOMAIN 19..88
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 233..280
FT /note="WD 1"
FT REPEAT 283..322
FT /note="WD 2"
FT REPEAT 324..359
FT /note="WD 3"
FT REPEAT 428..466
FT /note="WD 4"
FT REPEAT 548..586
FT /note="WD 5"
FT REGION 145..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 618..623
FT /note="PXXXPR"
FT /evidence="ECO:0000305"
FT MOTIF 678..683
FT /note="PXXXPR"
FT /evidence="ECO:0000305"
FT COMPBIAS 614..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..689
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBC3"
FT MOD_RES 163
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBC3"
FT MOD_RES 644
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBC3"
FT MOD_RES 646
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBC3"
SQ SEQUENCE 704 AA; 75885 MW; 1DA741D0003995D9 CRC64;
MAAAAPAVDG VPGRGPPGEV IHLNVGGKRF STSRQTLTWI PDSFFSSLLS GRISTLKDET
GAIFIDRDPT VFAPILNFLR TKELDPRGVH GSSLLHEAQF YGLTPLVRRL QLLEELDRSS
CGNVLFTGYL PPPVFPVKRR NRHSLVGPQQ AGGRPAPVRR SNTMPPNLGN AGLLGRMLDE
KSPPSPSGLP EEPGMVRLVC GHHNWIAVAY TQFLVCYRLK EASGWQLVFS SPRLDWPIER
LALTARVLGG ALGEHDKMVA VATGSEILLW ALQPEGGGSE IGVFHLGVPV EALFFVGNQL
IATSHTGRIG VWNAVTKHWQ VQEVQPITSY DAAGSFLLLG CNNGSIYYVD VQKFPLRMKD
NDLLVSELYR DPAEDGVTAL SVYLTPKTSD SGNWIEIAYG TSSGGVRVIV QHPETVGSGP
QLFQTFTVHR SPVTKIMLSE KHLISVCADS NHVRTWSVTR FRGMISTQPG STPLASFKIL
ALESADGHGG CSAGNDIGPY GERDDQQVFI QKVVPSASQL FVRLSSTGQR VCSVRSVDGS
PTTAFTVLEC EGSRRLGSRP RRYLLTGQAN GSLAMWDLTT AMDGLGQAPA GGLTEEELME
QLEQCDLAPL ASSRGSLPSP SPRTSLTSLH SAFSNTSLSS RRGSPSPPQA EARRRGGGSF
VERCQELVRS GPEPRRPPTP APRPSSGLGA PLVPPKTKLN ETSF
