ID   SHL2A_MOUSE             Reviewed;         189 AA.
AC   A2A9G7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Protein shisa-like-2A;
GN   Name=Shisal2a; Synonyms=Fam159a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; AL627238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS38833.1; -.
DR   RefSeq; NP_001092773.1; NM_001099303.2.
DR   AlphaFoldDB; A2A9G7; -.
DR   SMR; A2A9G7; -.
DR   STRING; 10090.ENSMUSP00000060463; -.
DR   PaxDb; A2A9G7; -.
DR   PRIDE; A2A9G7; -.
DR   Antibodypedia; 52572; 15 antibodies from 12 providers.
DR   Ensembl; ENSMUST00000053157; ENSMUSP00000060463; ENSMUSG00000059816.
DR   GeneID; 545667; -.
DR   KEGG; mmu:545667; -.
DR   UCSC; uc008ubb.2; mouse.
DR   CTD; 348378; -.
DR   MGI; MGI:3651644; Shisal2a.
DR   VEuPathDB; HostDB:ENSMUSG00000059816; -.
DR   eggNOG; ENOG502S15N; Eukaryota.
DR   GeneTree; ENSGT00940000161304; -.
DR   HOGENOM; CLU_107203_0_0_1; -.
DR   InParanoid; A2A9G7; -.
DR   OMA; DEVPPDC; -.
DR   OrthoDB; 1480293at2759; -.
DR   PhylomeDB; A2A9G7; -.
DR   TreeFam; TF335848; -.
DR   BioGRID-ORCS; 545667; 3 hits in 73 CRISPR screens.
DR   ChiTaRS; Shisal2a; mouse.
DR   PRO; PR:A2A9G7; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; A2A9G7; protein.
DR   Bgee; ENSMUSG00000059816; Expressed in morula and 30 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395; PTHR31395; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..189
FT                   /note="Protein shisa-like-2A"
FT                   /id="PRO_0000317721"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          98..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..114
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..175
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   189 AA;  20106 MW;  FAEB59F07EDF590B CRC64;
     MSGACSSYVS AEQEVVRGFS CPLPGGEAAA VFCCGFRDHK YCCDDPHSFF PYEHNYMWWL
     SIGALVGLST AAVVLLAFLI TACVLCYLFI SSKPQTKLDP GLSLQTTGSK EMSPDHHGLN
     TAIPMEVPGV SSPRQSSSSN THLESNKKQT VSPTCLPQNQ FMATVTASNI PGSPDEISVP
     TPGPHGPVP