ID   SHL2B_HUMAN             Reviewed;         160 AA.
AC   A6NKW6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Protein shisa-like-2B {ECO:0000312|HGNC:HGNC:34236};
GN   Name=SHISAL2B {ECO:0000312|HGNC:HGNC:34236}; Synonyms=FAM159B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; AC008898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS47220.1; -.
DR   RefSeq; NP_001157914.1; NM_001164442.1.
DR   AlphaFoldDB; A6NKW6; -.
DR   SMR; A6NKW6; -.
DR   STRING; 9606.ENSP00000373726; -.
DR   iPTMnet; A6NKW6; -.
DR   PhosphoSitePlus; A6NKW6; -.
DR   BioMuta; FAM159B; -.
DR   MassIVE; A6NKW6; -.
DR   PaxDb; A6NKW6; -.
DR   PeptideAtlas; A6NKW6; -.
DR   PRIDE; A6NKW6; -.
DR   Antibodypedia; 2195; 31 antibodies from 13 providers.
DR   DNASU; 100132916; -.
DR   Ensembl; ENST00000389074.6; ENSP00000373726.5; ENSG00000145642.12.
DR   GeneID; 100132916; -.
DR   KEGG; hsa:100132916; -.
DR   MANE-Select; ENST00000389074.6; ENSP00000373726.5; NM_001164442.2; NP_001157914.1.
DR   UCSC; uc021xzg.2; human.
DR   CTD; 100132916; -.
DR   GeneCards; SHISAL2B; -.
DR   HGNC; HGNC:34236; SHISAL2B.
DR   HPA; ENSG00000145642; Group enriched (brain, pancreas, stomach).
DR   neXtProt; NX_A6NKW6; -.
DR   OpenTargets; ENSG00000145642; -.
DR   PharmGKB; PA162386728; -.
DR   VEuPathDB; HostDB:ENSG00000145642; -.
DR   eggNOG; ENOG502S1JE; Eukaryota.
DR   GeneTree; ENSGT00940000161622; -.
DR   HOGENOM; CLU_140078_0_0_1; -.
DR   InParanoid; A6NKW6; -.
DR   OMA; YMWSLSV; -.
DR   OrthoDB; 1480293at2759; -.
DR   PhylomeDB; A6NKW6; -.
DR   TreeFam; TF335848; -.
DR   PathwayCommons; A6NKW6; -.
DR   BioGRID-ORCS; 100132916; 8 hits in 1061 CRISPR screens.
DR   GenomeRNAi; 100132916; -.
DR   Pharos; A6NKW6; Tdark.
DR   PRO; PR:A6NKW6; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; A6NKW6; protein.
DR   Bgee; ENSG00000145642; Expressed in islet of Langerhans and 75 other tissues.
DR   ExpressionAtlas; A6NKW6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395; PTHR31395; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..160
FT                   /note="Protein shisa-like-2B"
FT                   /id="PRO_0000317723"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         5
FT                   /note="S -> R (in dbSNP:rs16893053)"
FT                   /id="VAR_053995"
FT   VARIANT         111
FT                   /note="A -> P (in dbSNP:rs2305962)"
FT                   /id="VAR_053996"
SQ   SEQUENCE   160 AA;  17663 MW;  44B58414266BF516 CRC64;
     MSEASRLCSG YYSLNQSFVE PFQCPRRGEG AALQYCCGFA DLKYCCSEPG SYFPYKHSYM
     WSLSIGALIG LGIAALVLLA FVISVCVLCY LFLYTKPQRL DTGLKLQHLE ASSTQEGKSN
     GKTKALNSNA ASNATNETYY EADDIIQEKT MDATQIHIAY