ID   SHL2B_MOUSE             Reviewed;         158 AA.
AC   Q9D1Y9;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Protein shisa-like-2B;
GN   Name=Shisal2b; Synonyms=Fam159b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum, and Retina;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; AK020882; BAB32240.1; -; mRNA.
DR   EMBL; AK042897; BAC31399.1; -; mRNA.
DR   CCDS; CCDS26754.1; -.
DR   RefSeq; NP_084260.1; NM_029984.1.
DR   AlphaFoldDB; Q9D1Y9; -.
DR   SMR; Q9D1Y9; -.
DR   STRING; 10090.ENSMUSP00000042302; -.
DR   PhosphoSitePlus; Q9D1Y9; -.
DR   PaxDb; Q9D1Y9; -.
DR   PRIDE; Q9D1Y9; -.
DR   ProteomicsDB; 261032; -.
DR   Antibodypedia; 2195; 31 antibodies from 13 providers.
DR   Ensembl; ENSMUST00000043061; ENSMUSP00000042302; ENSMUSG00000042655.
DR   GeneID; 77803; -.
DR   KEGG; mmu:77803; -.
DR   UCSC; uc007rto.1; mouse.
DR   CTD; 100132916; -.
DR   MGI; MGI:1925053; Shisal2b.
DR   VEuPathDB; HostDB:ENSMUSG00000042655; -.
DR   eggNOG; ENOG502S1JE; Eukaryota.
DR   GeneTree; ENSGT00940000161622; -.
DR   HOGENOM; CLU_140078_0_0_1; -.
DR   InParanoid; Q9D1Y9; -.
DR   OMA; YMWSLSV; -.
DR   OrthoDB; 1480293at2759; -.
DR   PhylomeDB; Q9D1Y9; -.
DR   TreeFam; TF335848; -.
DR   BioGRID-ORCS; 77803; 7 hits in 74 CRISPR screens.
DR   PRO; PR:Q9D1Y9; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q9D1Y9; protein.
DR   Bgee; ENSMUSG00000042655; Expressed in islet of Langerhans and 38 other tissues.
DR   Genevisible; Q9D1Y9; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395; PTHR31395; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..158
FT                   /note="Protein shisa-like-2B"
FT                   /id="PRO_0000343652"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   158 AA;  17448 MW;  D572C9310875E9F7 CRC64;
     MSQSSRLCSG YYSLNRSFVE PFQCPQRGDG AALLYCCGFA DLKYCCSEPG SYFPYKHSYM
     WSLSIGALVG LGIAALVLLA FVISVCVLCY LFLYTKPQRL DNGLKLQHLE TSSTLEGNIN
     RKAKGLNAVS NSTNETFYEA DDGTQEKTMD ITQINIAC