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SHLB2_BOVIN
ID   SHLB2_BOVIN             Reviewed;         395 AA.
AC   Q08DK5;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Endophilin-B2;
DE   AltName: Full=SH3 domain-containing GRB2-like protein B2;
GN   Name=SH3GLB2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer, and heterodimer with SH3GLB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the endophilin family. {ECO:0000305}.
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DR   EMBL; BC123698; AAI23699.1; -; mRNA.
DR   RefSeq; NP_001070270.1; NM_001076802.1.
DR   AlphaFoldDB; Q08DK5; -.
DR   SMR; Q08DK5; -.
DR   STRING; 9913.ENSBTAP00000014049; -.
DR   PaxDb; Q08DK5; -.
DR   PRIDE; Q08DK5; -.
DR   GeneID; 504750; -.
DR   KEGG; bta:504750; -.
DR   CTD; 56904; -.
DR   eggNOG; KOG3725; Eukaryota.
DR   HOGENOM; CLU_043817_1_1_1; -.
DR   InParanoid; Q08DK5; -.
DR   OrthoDB; 803053at2759; -.
DR   TreeFam; TF313281; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0061024; P:membrane organization; IBA:GO_Central.
DR   CDD; cd11944; SH3_Endophilin_B2; 1.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR035640; Endophilin_B2_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF03114; BAR; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00721; BAR; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS51021; BAR; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Cytoplasm; Phosphoprotein; Reference proteome;
KW   SH3 domain.
FT   CHAIN           1..395
FT                   /note="Endophilin-B2"
FT                   /id="PRO_0000285843"
FT   DOMAIN          24..287
FT                   /note="BAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT   DOMAIN          335..395
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          1..27
FT                   /note="Membrane-binding amphipathic helix"
FT                   /evidence="ECO:0000250"
FT   COILED          116..132
FT                   /evidence="ECO:0000255"
FT   COILED          206..240
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NR46"
FT   MOD_RES         10
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NR46"
FT   MOD_RES         395
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5PPJ9"
SQ   SEQUENCE   395 AA;  44051 MW;  CE6F3FFB22FAFD0A CRC64;
     MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE SLLARADSTK NWTEKILRQT
     EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAE AASELGPTTP YGKTLIKVAE
     AEKHLGAAER DFIHTASINF LTPLRNFLEG DWKTISKERR LLQNRRLDLD ASKARLKKAK
     AAEAKATTVP DFQETRPRNY ILSASASALW NDEVDKAEQE LRVAQTEFDR QAEVTRLLLE
     GISSTHVNHL RCLHEFIESQ TTYYAQCYRH MLDLQKQLGR FPGTFVGTAE PASPPLSSTS
     PTTTAATMPM GPSVADLAPP GEAALRLEEV APPASGTRKA RVLYDYEAAD SSELALLADE
     LITVYSLPGM DPDWLIGERG NKKGKVPVTY LELLS
 
 
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