SHLB2_CHICK
ID SHLB2_CHICK Reviewed; 403 AA.
AC Q5ZJ81;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Endophilin-B2;
DE AltName: Full=SH3 domain-containing GRB2-like protein B2;
GN Name=SH3GLB2 {ECO:0000250|UniProtKB:Q9NR46}; ORFNames=RCJMB04_20c13;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000312|EMBL:CAG32212.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB {ECO:0000312|EMBL:CAG32212.1};
RC TISSUE=Bursa of Fabricius {ECO:0000312|EMBL:CAG32212.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- SUBUNIT: Homodimer, and heterodimer with SH3GLB1.
CC {ECO:0000250|UniProtKB:Q9NR46}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NR46}.
CC -!- SIMILARITY: Belongs to the endophilin family. {ECO:0000255}.
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DR EMBL; AJ720553; CAG32212.1; -; mRNA.
DR RefSeq; NP_001006200.1; NM_001006200.1.
DR AlphaFoldDB; Q5ZJ81; -.
DR SMR; Q5ZJ81; -.
DR STRING; 9031.ENSGALP00000007175; -.
DR PaxDb; Q5ZJ81; -.
DR Ensembl; ENSGALT00000082936; ENSGALP00000054000; ENSGALG00000039541.
DR GeneID; 417197; -.
DR KEGG; gga:417197; -.
DR CTD; 56904; -.
DR VEuPathDB; HostDB:geneid_417197; -.
DR eggNOG; KOG3725; Eukaryota.
DR GeneTree; ENSGT00940000155841; -.
DR HOGENOM; CLU_043817_1_1_1; -.
DR InParanoid; Q5ZJ81; -.
DR OrthoDB; 803053at2759; -.
DR PhylomeDB; Q5ZJ81; -.
DR TreeFam; TF313281; -.
DR PRO; PR:Q5ZJ81; -.
DR Proteomes; UP000000539; Chromosome 17.
DR Bgee; ENSGALG00000039541; Expressed in cerebellum and 12 other tissues.
DR ExpressionAtlas; Q5ZJ81; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0061024; P:membrane organization; IBA:GO_Central.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Reference proteome; SH3 domain.
FT CHAIN 1..403
FT /note="Endophilin-B2"
FT /id="PRO_0000307714"
FT DOMAIN 24..287
FT /note="BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT DOMAIN 343..403
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 1..27
FT /note="Membrane-binding amphipathic helix"
FT /evidence="ECO:0000250|UniProtKB:Q9Y371"
FT COILED 210..233
FT /evidence="ECO:0000255"
SQ SEQUENCE 403 AA; 44889 MW; FE4C1C3E03D18C25 CRC64;
MDFNVKKLAS DAGVFFSRAM QFTEEKLGQA EKTELDAHFE NLLARADSTK NWTEKILRQT
EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMTE AANDFGPGTP YGKTLIKVGE
TQRRLGAAER DFIHSASINF LTPLRNFLEG DWRTISKERR ILQNRRLDLD ACKARLKKAK
AAEAKAAAVP DFQETRPRNY VLSASASALW SDEVEKAEHE LRLTQTEFDR QAEVTRLLLE
GISSTHVNHL RCLHEFVESQ TNYYAQCYQY MLDLQKQLGR FSGTFVGNAE STSPPPAAAS
PPAVAATTLP AVPTIPVVPT IVGVPNTVAE SVLNPNEVKP PASGTRKARV LYDYEAADST
ELALLADEMI TVYSLPGMDP DWLIGERGNQ KGKVPVTYLE LLS
