SHLD1_BOVIN
ID SHLD1_BOVIN Reviewed; 206 AA.
AC Q2KIJ1;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Shieldin complex subunit 1 {ECO:0000250|UniProtKB:Q8IYI0};
DE AltName: Full=RINN1-REV7-interacting novel NHEJ regulator 3 {ECO:0000250|UniProtKB:Q8IYI0};
GN Name=SHLD1 {ECO:0000250|UniProtKB:Q8IYI0};
GN Synonyms=RINN3 {ECO:0000250|UniProtKB:Q8IYI0};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the shieldin complex, which plays an important
CC role in repair of DNA double-stranded breaks (DSBs). During G1 and S
CC phase of the cell cycle, the complex functions downstream of TP53BP1 to
CC promote non-homologous end joining (NHEJ) and suppress DNA end
CC resection. Mediates various NHEJ-dependent processes including
CC immunoglobulin class-switch recombination, and fusion of unprotected
CC telomeres. {ECO:0000250|UniProtKB:Q8IYI0}.
CC -!- SUBUNIT: Component of the shieldin complex, consisting of SHLD1, SHLD2,
CC SHLD3 and MAD2L2/REV7. Within the complex, SHLD2 forms a scaffold which
CC interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with
CC SHLD1 via its C-terminus. {ECO:0000250|UniProtKB:Q8IYI0}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q8IYI0}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC112619; AAI12620.1; -; mRNA.
DR RefSeq; NP_001040017.1; NM_001046552.2.
DR RefSeq; XP_005214904.1; XM_005214847.3.
DR RefSeq; XP_015329665.1; XM_015474179.1.
DR AlphaFoldDB; Q2KIJ1; -.
DR SMR; Q2KIJ1; -.
DR STRING; 9913.ENSBTAP00000039142; -.
DR PaxDb; Q2KIJ1; -.
DR Ensembl; ENSBTAT00000039347; ENSBTAP00000039142; ENSBTAG00000014048.
DR Ensembl; ENSBTAT00000083140; ENSBTAP00000064111; ENSBTAG00000014048.
DR GeneID; 615129; -.
DR KEGG; bta:615129; -.
DR CTD; 149840; -.
DR VEuPathDB; HostDB:ENSBTAG00000014048; -.
DR VGNC; VGNC:49170; SHLD1.
DR eggNOG; ENOG502SUXK; Eukaryota.
DR GeneTree; ENSGT00390000014969; -.
DR HOGENOM; CLU_090358_0_0_1; -.
DR InParanoid; Q2KIJ1; -.
DR OMA; VLRSFQM; -.
DR TreeFam; TF336046; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000014048; Expressed in semen and 108 other tissues.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:2001034; P:positive regulation of double-strand break repair via nonhomologous end joining; IBA:GO_Central.
DR GO; GO:0045830; P:positive regulation of isotype switching; IBA:GO_Central.
DR InterPro; IPR027821; SHLD1.
DR PANTHER; PTHR36863; PTHR36863; 1.
DR Pfam; PF15021; DUF4521; 1.
PE 2: Evidence at transcript level;
KW Chromosome; DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..206
FT /note="Shieldin complex subunit 1"
FT /id="PRO_0000286611"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 33..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 206 AA; 23268 MW; 99EEDA41774990E2 CRC64;
MATQETTPGS QTEESNALDL PSAYDIRDYV LQRPSQQTNS EAFSSEEACS IPCSSDVDPD
SSNLNTEQND SWTSENFWFY PSVKGQPETK EEDDGLRKSL DKFYEVFGNP QPASGNSLST
SVCQCLSQKI NELKDQENQT YTLRSFQMAR VIFNQNGCSI LQKHSRDAHF YPVREGSTSL
QDEKLTPGLS KDIIHFLLQQ NLMKDQ
