BH007_ARATH
ID BH007_ARATH Reviewed; 302 AA.
AC Q93Y00; Q9SA66;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Transcription factor bHLH7;
DE AltName: Full=Basic helix-loop-helix protein 7;
DE Short=AtbHLH7;
DE Short=bHLH 7;
DE AltName: Full=Transcription factor EN 92;
DE AltName: Full=bHLH transcription factor bHLH007;
GN Name=BHLH7; Synonyms=EN92; OrderedLocusNames=At1g03040; ORFNames=F10O3.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q93Y00; F4I3E6: At1g49830; NbExp=4; IntAct=EBI-4442198, EBI-15195341;
CC Q93Y00; Q94JL3: BHLH112; NbExp=3; IntAct=EBI-4442198, EBI-3133192;
CC Q93Y00; Q8GXT3: BHLH123; NbExp=3; IntAct=EBI-4442198, EBI-15194527;
CC Q93Y00; Q7XHI5: BHLH133; NbExp=3; IntAct=EBI-4442198, EBI-15195839;
CC Q93Y00; Q7XJU2: BHLH153; NbExp=4; IntAct=EBI-4442198, EBI-4427748;
CC Q93Y00; Q7XJU1: BHLH154; NbExp=3; IntAct=EBI-4442198, EBI-15195083;
CC Q93Y00; Q9SN74: BHLH47; NbExp=3; IntAct=EBI-4442198, EBI-4437532;
CC Q93Y00; Q8S3D1: BHLH68; NbExp=4; IntAct=EBI-4442198, EBI-15192111;
CC Q93Y00; Q9ZUG9: LRL1; NbExp=3; IntAct=EBI-4442198, EBI-15195343;
CC Q93Y00; Q9C707: RHD6; NbExp=3; IntAct=EBI-4442198, EBI-4424338;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q93Y00-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems
CC and flowers. {ECO:0000269|PubMed:12679534}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD25805.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF251692; AAL55714.2; -; mRNA.
DR EMBL; AC006550; AAD25805.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27518.1; -; Genomic_DNA.
DR EMBL; AY054469; AAK96661.1; -; mRNA.
DR EMBL; AY114633; AAM47952.1; -; mRNA.
DR PIR; B86161; B86161.
DR RefSeq; NP_001184895.1; NM_001197966.1.
DR RefSeq; NP_563672.1; NM_100185.3. [Q93Y00-1]
DR AlphaFoldDB; Q93Y00; -.
DR SMR; Q93Y00; -.
DR BioGRID; 24681; 56.
DR IntAct; Q93Y00; 54.
DR STRING; 3702.AT1G03040.1; -.
DR PaxDb; Q93Y00; -.
DR EnsemblPlants; AT1G03040.1; AT1G03040.1; AT1G03040. [Q93Y00-1]
DR GeneID; 839446; -.
DR Gramene; AT1G03040.1; AT1G03040.1; AT1G03040. [Q93Y00-1]
DR KEGG; ath:AT1G03040; -.
DR Araport; AT1G03040; -.
DR TAIR; locus:2007534; AT1G03040.
DR eggNOG; ENOG502QPM5; Eukaryota.
DR InParanoid; Q93Y00; -.
DR PhylomeDB; Q93Y00; -.
DR PRO; PR:Q93Y00; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q93Y00; baseline and differential.
DR Genevisible; Q93Y00; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..302
FT /note="Transcription factor bHLH7"
FT /id="PRO_0000358726"
FT DOMAIN 150..199
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 124..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 32704 MW; 2D63EACD453AF945 CRC64;
MANNNNIPHD SISDPSPTDD FFEQILGLSN FSGSSGSGLS GIGGVGPPPM MLQLGSGNEG
NHNHMGAIGG GGPVGFHNQM FPLGLSLDQG KGHGFLKPDE TGKRFQDDVL DNRCSSMKPI
FHGQPMSQPA PPMPHQQSTI RPRVRARRGQ ATDPHSIAER LRRERIAERI RSLQELVPTV
NKTDRAAMID EIVDYVKFLR LQVKVLSMSR LGGAGAVAPL VTEMPLSSSV EDETQAVWEK
WSNDGTERQV AKLMEENVGA AMQLLQSKAL CIMPISLAMA IYHSQPPDTS SSIVKPEMNP
PP
