ID   SHOC2_CAEBR             Reviewed;         559 AA.
AC   A8XWW4;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Leucine-rich repeat protein soc-2;
DE   AltName: Full=Suppressor of Clr protein 2;
DE   AltName: Full=Suppressor of activated let-60 Ras protein 8;
GN   Name=soc-2; Synonyms=sur-8; ORFNames=CBG19995;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC       activation. Probably acts as a regulatory subunit of protein
CC       phosphatase that specifically dephosphorylates Raf kinase and
CC       stimulates Raf activity at specialized signaling complexes upon Ras
CC       activation. Required for vulval development. Involved in fluid
CC       homeostasis. Plays a role in nicotinic acetylcholine receptor (nAChR)-
CC       mediated sensitivity to nicotine. {ECO:0000250|UniProtKB:Q22875}.
CC   -!- SUBUNIT: Interacts with let-60. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR   EMBL; HE601481; CAP37133.1; -; Genomic_DNA.
DR   RefSeq; XP_002633925.1; XM_002633879.1.
DR   AlphaFoldDB; A8XWW4; -.
DR   SMR; A8XWW4; -.
DR   STRING; 6238.CBG19995; -.
DR   EnsemblMetazoa; CBG19995b.1; CBG19995b.1; WBGene00039104.
DR   GeneID; 8575921; -.
DR   KEGG; cbr:CBG_19995; -.
DR   CTD; 8575921; -.
DR   WormBase; CBG19995a; CBP39480; WBGene00039104; Cbr-soc-2.
DR   eggNOG; KOG0619; Eukaryota.
DR   HOGENOM; CLU_000288_18_23_1; -.
DR   InParanoid; A8XWW4; -.
DR   OMA; NQFTSYP; -.
DR   OrthoDB; 287114at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027036; SHOC2.
DR   PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   SMART; SM00369; LRR_TYP; 17.
DR   PROSITE; PS51450; LRR; 17.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..559
FT                   /note="Leucine-rich repeat protein soc-2"
FT                   /id="PRO_0000385630"
FT   REPEAT          74..95
FT                   /note="LRR 1"
FT   REPEAT          97..118
FT                   /note="LRR 2"
FT   REPEAT          120..141
FT                   /note="LRR 3"
FT   REPEAT          143..164
FT                   /note="LRR 4"
FT   REPEAT          166..187
FT                   /note="LRR 5"
FT   REPEAT          189..210
FT                   /note="LRR 6"
FT   REPEAT          212..233
FT                   /note="LRR 7"
FT   REPEAT          235..257
FT                   /note="LRR 8"
FT   REPEAT          258..279
FT                   /note="LRR 9"
FT   REPEAT          281..302
FT                   /note="LRR 10"
FT   REPEAT          305..326
FT                   /note="LRR 11"
FT   REPEAT          329..350
FT                   /note="LRR 12"
FT   REPEAT          353..374
FT                   /note="LRR 13"
FT   REPEAT          376..397
FT                   /note="LRR 14"
FT   REPEAT          399..420
FT                   /note="LRR 15"
FT   REPEAT          422..443
FT                   /note="LRR 16"
FT   REPEAT          445..466
FT                   /note="LRR 17"
FT   REPEAT          468..489
FT                   /note="LRR 18"
FT   REPEAT          491..513
FT                   /note="LRR 19"
FT   REPEAT          515..536
FT                   /note="LRR 20"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   559 AA;  62523 MW;  43A128DCF6345F3A CRC64;
     METSKEFEFR PAKETSRSKS PGGIVGRLSN FARNKARHSL SEKGSNSVGG SGGSGFDKPR
     KDLLKEFHKC KEAQDQRLDL SSIEITSIPS PIKELTQLTE LFLYKNKLTC LPTEIGQLVN
     LKKLGLSENA LSSLPDSLSS LESLETLDLR HNKLTEVPAV IYKITSLETL WLRYNRIVAV
     DEQIGNLQKL KMLDVRENKI RELPSAIGKL SSLVVCLVSY NHLTRVPEEI GECHALTQLD
     LQHNDLSELP YSIGKLTNLV RIGIRYNKIR CIPSELESCQ QLEEFIVESN HLQLLPPNLL
     TMLPKIHTVN LSRNELTAFP AGGPQQFVPT VTINMEHNQI SKIPIGIFSK ATRLTKLNLK
     ENELVSLPLD MGSWTSITEL NLSTNQLKVL PEDIEKLVNL EILVLSNNQL KKLPNQIGNL
     KKLRELDLEE NELETVPTEI GFLQHLTKLW VQSNKIVTLP RSIGNLCSLQ DLRLGENNLT
     AIPEEIGHLD SLKSLYLNDN SSLHNLPFEL ALCQSLEIMS IENSPLSQIP PEITAGGPSL
     VIQYLKMQGP YRGVVMTGQ