BH013_ARATH
ID BH013_ARATH Reviewed; 590 AA.
AC Q9LNJ5; Q8S3F5;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=Transcription factor bHLH13;
DE AltName: Full=Basic helix-loop-helix protein 13;
DE Short=AtbHLH13;
DE Short=bHLH 13;
DE AltName: Full=Transcription factor EN 39;
DE AltName: Full=bHLH transcription factor bHLH013;
GN Name=BHLH13; Synonyms=EN39; OrderedLocusNames=At1g01260; ORFNames=F6F3.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION BY UV LIGHT, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia; TISSUE=Root;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q9LNJ5; F4JI72: At4g03250; NbExp=4; IntAct=EBI-4434261, EBI-15192535;
CC Q9LNJ5; O23487: BHLH3; NbExp=3; IntAct=EBI-4434261, EBI-15196271;
CC Q9LNJ5; Q8H1G0: GATA28; NbExp=6; IntAct=EBI-4434261, EBI-4435064;
CC Q9LNJ5; Q8LA53: MBD2; NbExp=3; IntAct=EBI-4434261, EBI-4425826;
CC Q9LNJ5; Q9LUA3: NIMIN-2; NbExp=3; IntAct=EBI-4434261, EBI-541107;
CC Q9LNJ5; Q9LMA8: TIFY10A; NbExp=9; IntAct=EBI-4434261, EBI-1388539;
CC Q9LNJ5; Q9S7M2: TIFY10B; NbExp=6; IntAct=EBI-4434261, EBI-1792563;
CC Q9LNJ5; Q9LDU5: TIFY11A; NbExp=6; IntAct=EBI-4434261, EBI-2312095;
CC Q9LNJ5; Q9C9E3: TIFY11B; NbExp=5; IntAct=EBI-4434261, EBI-2312120;
CC Q9LNJ5; Q9M246: TIFY3A; NbExp=5; IntAct=EBI-4434261, EBI-2312209;
CC Q9LNJ5; Q9C5K8: TIFY3B; NbExp=7; IntAct=EBI-4434261, EBI-2312231;
CC Q9LNJ5; Q8LBM2: TIFY5A; NbExp=7; IntAct=EBI-4434261, EBI-2312143;
CC Q9LNJ5; Q58G47: TIFY6A; NbExp=4; IntAct=EBI-4434261, EBI-2312053;
CC Q9LNJ5; Q9LVI4: TIFY6B; NbExp=5; IntAct=EBI-4434261, EBI-1792431;
CC Q9LNJ5; Q8W4J8: TIFY7; NbExp=5; IntAct=EBI-4434261, EBI-1792583;
CC Q9LNJ5; Q93ZM9: TIFY9; NbExp=4; IntAct=EBI-4434261, EBI-2312172;
CC Q9LNJ5; Q9LDT3: YAB4; NbExp=5; IntAct=EBI-4434261, EBI-1115523;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- INDUCTION: By UV treatment. {ECO:0000269|PubMed:12679534}.
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DR EMBL; AF251698; AAL55720.1; -; mRNA.
DR EMBL; AC023628; AAF97322.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27262.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27263.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27264.1; -; Genomic_DNA.
DR EMBL; AF488559; AAM10932.1; -; mRNA.
DR EMBL; AY079012; AAL84968.1; -; mRNA.
DR EMBL; AY120752; AAM53310.1; -; mRNA.
DR EMBL; BT004517; AAO42763.1; -; mRNA.
DR PIR; H86142; H86142.
DR RefSeq; NP_001077440.1; NM_001083971.1.
DR RefSeq; NP_001184883.1; NM_001197954.2.
DR RefSeq; NP_171634.1; NM_100009.3.
DR AlphaFoldDB; Q9LNJ5; -.
DR SMR; Q9LNJ5; -.
DR BioGRID; 24780; 23.
DR IntAct; Q9LNJ5; 23.
DR STRING; 3702.AT1G01260.1; -.
DR iPTMnet; Q9LNJ5; -.
DR PaxDb; Q9LNJ5; -.
DR PRIDE; Q9LNJ5; -.
DR ProteomicsDB; 240347; -.
DR EnsemblPlants; AT1G01260.1; AT1G01260.1; AT1G01260.
DR EnsemblPlants; AT1G01260.2; AT1G01260.2; AT1G01260.
DR EnsemblPlants; AT1G01260.3; AT1G01260.3; AT1G01260.
DR GeneID; 839545; -.
DR Gramene; AT1G01260.1; AT1G01260.1; AT1G01260.
DR Gramene; AT1G01260.2; AT1G01260.2; AT1G01260.
DR Gramene; AT1G01260.3; AT1G01260.3; AT1G01260.
DR KEGG; ath:AT1G01260; -.
DR Araport; AT1G01260; -.
DR TAIR; locus:2035237; AT1G01260.
DR eggNOG; ENOG502QUFW; Eukaryota.
DR HOGENOM; CLU_021132_0_1_1; -.
DR InParanoid; Q9LNJ5; -.
DR OMA; RFMFSNP; -.
DR OrthoDB; 828530at2759; -.
DR PhylomeDB; Q9LNJ5; -.
DR PRO; PR:Q9LNJ5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LNJ5; baseline and differential.
DR Genevisible; Q9LNJ5; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0010629; P:negative regulation of gene expression; IGI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045084; AIB/MYC-like.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR025610; MYC/MYB_N.
DR PANTHER; PTHR11514; PTHR11514; 1.
DR Pfam; PF14215; bHLH-MYC_N; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..590
FT /note="Transcription factor bHLH13"
FT /id="PRO_0000358730"
FT DOMAIN 429..478
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 274..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 134
FT /note="E -> K (in Ref. 1; AAM10932)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 590 AA; 66002 MW; 0BCCF4DB5593D95E CRC64;
MNIGRLVWNE DDKAIVASLL GKRALDYLLS NSVSNANLLM TLGSDENLQN KLSDLVERPN
ASNFSWNYAI FWQISRSKAG DLVLCWGDGY CREPKEGEKS EIVRILSMGR EEETHQTMRK
RVLQKLHDLF GGSEEENCAL GLDRVTDTEM FLLSSMYFSF PRGEGGPGKC FASAKPVWLS
DVVNSGSDYC VRSFLAKSAG IQTVVLVPTD LGVVELGSTS CLPESEDSIL SIRSLFTSSL
PPVRAVALPV TVAEKIDDNR TKIFGKDLHN SGFLQHHQHH QQQQQQPPQQ QQHRQFREKL
TVRKMDDRAP KRLDAYPNNG NRFMFSNPGT NNNTLLSPTW VQPENYTRPI NVKEVPSTDE
FKFLPLQQSS QRLLPPAQMQ IDFSAASSRA SENNSDGEGG GEWADAVGAD ESGNNRPRKR
GRRPANGRAE ALNHVEAERQ RREKLNQRFY ALRSVVPNIS KMDKASLLGD AVSYINELHA
KLKVMEAERE RLGYSSNPPI SLDSDINVQT SGEDVTVRIN CPLESHPASR IFHAFEESKV
EVINSNLEVS QDTVLHTFVV KSEELTKEKL ISALSREQTN SVQSRTSSGR
