SHOC2_CHICK
ID SHOC2_CHICK Reviewed; 529 AA.
AC Q5F4C4;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Leucine-rich repeat protein SHOC-2;
DE AltName: Full=Protein soc-2 homolog;
DE AltName: Full=Protein sur-8 homolog;
GN Name=SHOC2; ORFNames=RCJMB04_1b13;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Regulatory subunit of protein phosphatase 1 (PP1c) that acts
CC as a M-Ras/MRAS effector and participates in MAPK pathway activation.
CC Upon M-Ras/MRAS activation, targets PP1c to specifically
CC dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and
CC stimulate RAF1 activity at specialized signaling complexes (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR EMBL; AJ851376; CAH65010.1; -; mRNA.
DR RefSeq; NP_001026407.1; NM_001031236.1.
DR AlphaFoldDB; Q5F4C4; -.
DR SMR; Q5F4C4; -.
DR STRING; 9031.ENSGALP00000014251; -.
DR PaxDb; Q5F4C4; -.
DR GeneID; 423894; -.
DR KEGG; gga:423894; -.
DR CTD; 8036; -.
DR VEuPathDB; HostDB:geneid_423894; -.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; Q5F4C4; -.
DR PhylomeDB; Q5F4C4; -.
DR PRO; PR:Q5F4C4; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000164; C:protein phosphatase type 1 complex; ISS:UniProtKB.
DR GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR GO; GO:0019903; F:protein phosphatase binding; ISS:UniProtKB.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027036; SHOC2.
DR PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00369; LRR_TYP; 15.
DR PROSITE; PS51450; LRR; 17.
PE 2: Evidence at transcript level;
KW Cytoplasm; Leucine-rich repeat; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..529
FT /note="Leucine-rich repeat protein SHOC-2"
FT /id="PRO_0000385627"
FT REPEAT 99..122
FT /note="LRR 1"
FT REPEAT 123..145
FT /note="LRR 2"
FT REPEAT 146..168
FT /note="LRR 3"
FT REPEAT 169..191
FT /note="LRR 4"
FT REPEAT 193..214
FT /note="LRR 5"
FT REPEAT 215..237
FT /note="LRR 6"
FT REPEAT 239..260
FT /note="LRR 7"
FT REPEAT 262..283
FT /note="LRR 8"
FT REPEAT 284..306
FT /note="LRR 9"
FT REPEAT 307..329
FT /note="LRR 10"
FT REPEAT 331..353
FT /note="LRR 11"
FT REPEAT 354..377
FT /note="LRR 12"
FT REPEAT 379..400
FT /note="LRR 13"
FT REPEAT 401..424
FT /note="LRR 14"
FT REPEAT 425..447
FT /note="LRR 15"
FT REPEAT 448..471
FT /note="LRR 16"
FT REPEAT 473..493
FT /note="LRR 17"
FT REPEAT 494..516
FT /note="LRR 18"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 59162 MW; 7D7090387ABBA363 CRC64;
MSSNLGKEKD CKEKDPKVPS SKEREKESKA SGGFGKESKE KEPKTKGKDA KDGKKDSSST
QPGVAFSVDN TIKRPNPATG TRKKSSNAEV IKELNKCREE NSMRLDLAKR SIHMLPSAVK
ELTQLTELYL YSNKLQSLPA EVGCLVNLVT LALSENSLTS LPDSLDNLKK LRMLDLRHNK
LREIPSVVYR LTSLATLYLR FNRITTVEKD IKTLSKLTML SIRENKIKQL PAEIGELCNL
ITLDVAHNQL EHLPEEIGSC TQITNLDLQH NELLDLPETI GNLSSLSRLG LRYNRLSAIP
KSLAKCSELD ELNLENNNIS TLPEGLLSSL VKLTSLTLAR NCFQSYPVGG PSQFSTIYSL
NMEHNRINKI PFGIFSRAKV LSKLNMKDNQ LTSLPLDFGT WTSMVELNLA TNQLTKIPED
VSGLVSLEVL ILSNNLLKKL PHGIGNLRKL RELDLEENKL ESLPNEIAYL KDLQKLVLTN
NQLTTLPRGI GHLTNLTHLG LGENLLTHLP EEIGKILFFF FFNVSFLFV
