ID   SHOC2_DANRE             Reviewed;         561 AA.
AC   Q1L8Y7; A0JMD9;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Leucine-rich repeat protein SHOC-2;
DE   AltName: Full=Protein soc-2 homolog;
DE   AltName: Full=Protein sur-8 homolog;
GN   Name=shoc2; ORFNames=si:ch211-159c12.3, si:ch211-197i12.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory subunit of protein phosphatase 1 (PP1c) that acts
CC       as a M-Ras/MRAS effector and participates in MAPK pathway activation.
CC       Upon M-Ras/MRAS activation, targets PP1c to specifically
CC       dephosphorylate the 'Ser-259' inhibitory site of raf1 kinase and
CC       stimulate raf1 activity at specialized signaling complexes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q1L8Y7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q1L8Y7-2; Sequence=VSP_038197;
CC   -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR   EMBL; AL772158; CAK04058.1; -; Genomic_DNA.
DR   EMBL; CR450802; CAK04354.1; -; Genomic_DNA.
DR   EMBL; BC125839; AAI25840.1; -; mRNA.
DR   EMBL; BC155579; AAI55580.1; -; mRNA.
DR   RefSeq; NP_001038251.1; NM_001044786.1. [Q1L8Y7-1]
DR   RefSeq; XP_005161853.1; XM_005161796.3. [Q1L8Y7-1]
DR   AlphaFoldDB; Q1L8Y7; -.
DR   SMR; Q1L8Y7; -.
DR   STRING; 7955.ENSDARP00000110805; -.
DR   PaxDb; Q1L8Y7; -.
DR   Ensembl; ENSDART00000059882; ENSDARP00000059881; ENSDARG00000040853. [Q1L8Y7-1]
DR   Ensembl; ENSDART00000184718; ENSDARP00000150764; ENSDARG00000116564. [Q1L8Y7-1]
DR   Ensembl; ENSDART00000191544; ENSDARP00000156603; ENSDARG00000112058. [Q1L8Y7-1]
DR   GeneID; 555476; -.
DR   KEGG; dre:555476; -.
DR   CTD; 8036; -.
DR   ZFIN; ZDB-GENE-050208-523; shoc2.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000156270; -.
DR   HOGENOM; CLU_000288_18_23_1; -.
DR   InParanoid; Q1L8Y7; -.
DR   OMA; NQFTSYP; -.
DR   OrthoDB; 287114at2759; -.
DR   PhylomeDB; Q1L8Y7; -.
DR   TreeFam; TF315742; -.
DR   Reactome; R-DRE-5673000; RAF activation.
DR   PRO; PR:Q1L8Y7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000040853; Expressed in mature ovarian follicle and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000164; C:protein phosphatase type 1 complex; ISS:UniProtKB.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR   GO; GO:0019903; F:protein phosphatase binding; ISS:UniProtKB.
DR   GO; GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027036; SHOC2.
DR   PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00369; LRR_TYP; 15.
DR   PROSITE; PS51450; LRR; 18.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Leucine-rich repeat; Nucleus;
KW   Reference proteome; Repeat.
FT   CHAIN           1..561
FT                   /note="Leucine-rich repeat protein SHOC-2"
FT                   /id="PRO_0000385628"
FT   REPEAT          80..101
FT                   /note="LRR 1"
FT   REPEAT          103..124
FT                   /note="LRR 2"
FT   REPEAT          126..148
FT                   /note="LRR 3"
FT   REPEAT          149..170
FT                   /note="LRR 4"
FT   REPEAT          172..193
FT                   /note="LRR 5"
FT   REPEAT          195..216
FT                   /note="LRR 6"
FT   REPEAT          218..239
FT                   /note="LRR 7"
FT   REPEAT          241..262
FT                   /note="LRR 8"
FT   REPEAT          264..286
FT                   /note="LRR 9"
FT   REPEAT          287..308
FT                   /note="LRR 10"
FT   REPEAT          311..332
FT                   /note="LRR 11"
FT   REPEAT          335..356
FT                   /note="LRR 12"
FT   REPEAT          359..379
FT                   /note="LRR 13"
FT   REPEAT          382..403
FT                   /note="LRR 14"
FT   REPEAT          405..427
FT                   /note="LRR 15"
FT   REPEAT          428..449
FT                   /note="LRR 16"
FT   REPEAT          451..473
FT                   /note="LRR 17"
FT   REPEAT          474..495
FT                   /note="LRR 18"
FT   REPEAT          497..519
FT                   /note="LRR 19"
FT   REPEAT          521..542
FT                   /note="LRR 20"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         261..561
FT                   /note="NLASINRLGLRYNRLSAIPRSLAKCRELEELNLENNNISVLPEGLLSSLVNL
FT                   TSLTLARNCFQSYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLT
FT                   SLPLDFGTWTSMVELNLATNQLTKIPEDICGLVSLEMLTLSNNLLKKLPYGIGNLRKLR
FT                   ELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTYLGLGENLLQHLP
FT                   EEIGTLENLEDLYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFII
FT                   QFLKMQGPYRAMV -> EDELKKTSLGLLPVFLF (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_038197"
SQ   SEQUENCE   561 AA;  62696 MW;  E805D3A5EC4516F1 CRC64;
     MSSTLGKDKD SKEREPKAEG KSKTKGKDAK DGKKDTSGAS PAVAFTLDST IKRPNPPPST
     RKKSSNAEVI KELNKCREEN SMRLDLSKRS IHLLPSSIKE LTQLTELYLY SNKLQSLPPE
     VGCLSGLVTL ALSENSLTSL PDSLDNLKKL RMLDLRHNKL REIPAVVYRV SSLTTLYLRF
     NRITTVEKDI KNLSKLTMLS IRENKIKQLP AEIGELCNLI TLDVAHNQLE HLPKEIGNCT
     QITNLDLQHN DLLDLPETIG NLASINRLGL RYNRLSAIPR SLAKCRELEE LNLENNNISV
     LPEGLLSSLV NLTSLTLARN CFQSYPVGGP SQFSTIYSLN MEHNRINKIP FGIFSRAKVL
     SKLNMKDNQL TSLPLDFGTW TSMVELNLAT NQLTKIPEDI CGLVSLEMLT LSNNLLKKLP
     YGIGNLRKLR ELDLEENKLE SLPNEIAYLK DLQKLVLTNN QLTTLPRGIG HLTNLTYLGL
     GENLLQHLPE EIGTLENLED LYLNDNPNLH SLPFELALCS KLSIMSIENC PLSHLPPQIV
     AGGPSFIIQF LKMQGPYRAM V