ID   SHOC2_NEMVE             Reviewed;         577 AA.
AC   A7SFP1;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Leucine-rich repeat protein soc-2 homolog;
GN   ORFNames=v1g189306;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC       activation. Probably acts as a regulatory subunit of protein
CC       phosphatase that specifically dephosphorylates Raf kinase and stimulate
CC       Raf activity at specialized signaling complexes upon Ras activation (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR   EMBL; DS469645; EDO37499.1; -; Genomic_DNA.
DR   RefSeq; XP_001629562.1; XM_001629512.1.
DR   AlphaFoldDB; A7SFP1; -.
DR   SMR; A7SFP1; -.
DR   STRING; 45351.EDO37499; -.
DR   EnsemblMetazoa; EDO37499; EDO37499; NEMVEDRAFT_v1g189306.
DR   GeneID; 5509046; -.
DR   KEGG; nve:5509046; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   HOGENOM; CLU_000288_18_23_1; -.
DR   InParanoid; A7SFP1; -.
DR   OMA; NQFTSYP; -.
DR   OrthoDB; 287114at2759; -.
DR   PhylomeDB; A7SFP1; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027036; SHOC2.
DR   PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00369; LRR_TYP; 14.
DR   PROSITE; PS51450; LRR; 16.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..577
FT                   /note="Leucine-rich repeat protein soc-2 homolog"
FT                   /id="PRO_0000385632"
FT   REPEAT          87..109
FT                   /note="LRR 1"
FT   REPEAT          110..131
FT                   /note="LRR 2"
FT   REPEAT          133..155
FT                   /note="LRR 3"
FT   REPEAT          156..177
FT                   /note="LRR 4"
FT   REPEAT          179..201
FT                   /note="LRR 5"
FT   REPEAT          202..223
FT                   /note="LRR 6"
FT   REPEAT          225..246
FT                   /note="LRR 7"
FT   REPEAT          248..269
FT                   /note="LRR 8"
FT   REPEAT          271..292
FT                   /note="LRR 9"
FT   REPEAT          294..315
FT                   /note="LRR 10"
FT   REPEAT          318..339
FT                   /note="LRR 11"
FT   REPEAT          342..363
FT                   /note="LRR 12"
FT   REPEAT          366..387
FT                   /note="LRR 13"
FT   REPEAT          389..410
FT                   /note="LRR 14"
FT   REPEAT          412..434
FT                   /note="LRR 15"
FT   REPEAT          435..456
FT                   /note="LRR 16"
FT   REPEAT          458..479
FT                   /note="LRR 17"
FT   REPEAT          481..502
FT                   /note="LRR 18"
FT   REPEAT          504..526
FT                   /note="LRR 19"
FT   REPEAT          528..549
FT                   /note="LRR 20"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   577 AA;  64239 MW;  A3A5335718795B79 CRC64;
     MRRTKGRTDS PDVQSLNINA DYGEAASLTA DDSTAHKSDK KHDPEAKKQV TITVQPGVKP
     KPTVKKRSTP SADLDIHKEI QKCREEGATR LDLSKAAVTV LPKELKELTS LRELYLYGNR
     IAVLPPEVGL LPNLETLALS ENNLTTLPDN LVKLTKLKVL DLRHNKIKEI PDVIYKLTTL
     TTLYLRFNRI SVVESGIGNL KLLERLSLRE NKIKILPRVI GQLVHLVTLD ISHNHIENLP
     AEIGNCVHMT SLDLQHNDIP SLPDSIGRLT AMTRLGLRYN QLSSLPDSLA NCSGIDEFNI
     EGNNIAELPE KLLSSLKNLT SLTLSRNKFE VFPAGPPKQF CQVNTFIMEH NRMQKIPFGV
     FNKAKYLSKL NVKDNQLTSL PLDFGSWISL VELNVATNQI SKLPEDIQWL VNLEVLILSN
     NLLKKLPRGI GALRKLRVLD IEENKLESIP TEIEYLRSLE RLVLQSNCLG SLPRSIGYLS
     SVTYLSVGEN ELVSVPQEIG NMESLEQLYL NDNENLQSLP YELVLCGSLQ IMSIENCPLS
     ALPSQIVAGG PSLVIQYLRL QGPYNGMVDT GVPTSDV