ID   SHOC2_XENLA             Reviewed;         577 AA.
AC   Q8AVI4;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Leucine-rich repeat protein SHOC-2;
DE   AltName: Full=Protein soc-2 homolog;
DE   AltName: Full=Protein sur-8 homolog;
GN   Name=shoc2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory subunit of protein phosphatase 1 (PP1c) that acts
CC       as a M-Ras/MRAS effector and participates in MAPK pathway activation.
CC       Upon M-Ras/MRAS activation, targets PP1c to specifically
CC       dephosphorylate the 'Ser-259' inhibitory site of raf1 kinase and
CC       stimulate raf1 activity at specialized signaling complexes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR   EMBL; BC042263; AAH42263.1; -; mRNA.
DR   RefSeq; NP_001080350.1; NM_001086881.1.
DR   AlphaFoldDB; Q8AVI4; -.
DR   SMR; Q8AVI4; -.
DR   IntAct; Q8AVI4; 1.
DR   DNASU; 380042; -.
DR   GeneID; 380042; -.
DR   KEGG; xla:380042; -.
DR   CTD; 380042; -.
DR   Xenbase; XB-GENE-493506; shoc2.S.
DR   OrthoDB; 287114at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 380042; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000164; C:protein phosphatase type 1 complex; ISS:UniProtKB.
DR   GO; GO:0019903; F:protein phosphatase binding; ISS:UniProtKB.
DR   GO; GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027036; SHOC2.
DR   PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR   Pfam; PF13855; LRR_8; 5.
DR   SMART; SM00369; LRR_TYP; 16.
DR   PROSITE; PS51450; LRR; 17.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Leucine-rich repeat; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..577
FT                   /note="Leucine-rich repeat protein SHOC-2"
FT                   /id="PRO_0000385629"
FT   REPEAT          96..118
FT                   /note="LRR 1"
FT   REPEAT          119..140
FT                   /note="LRR 2"
FT   REPEAT          142..164
FT                   /note="LRR 3"
FT   REPEAT          165..186
FT                   /note="LRR 4"
FT   REPEAT          188..209
FT                   /note="LRR 5"
FT   REPEAT          211..232
FT                   /note="LRR 6"
FT   REPEAT          234..255
FT                   /note="LRR 7"
FT   REPEAT          257..278
FT                   /note="LRR 8"
FT   REPEAT          280..302
FT                   /note="LRR 9"
FT   REPEAT          303..324
FT                   /note="LRR 10"
FT   REPEAT          327..348
FT                   /note="LRR 11"
FT   REPEAT          351..372
FT                   /note="LRR 12"
FT   REPEAT          375..395
FT                   /note="LRR 13"
FT   REPEAT          398..419
FT                   /note="LRR 14"
FT   REPEAT          421..443
FT                   /note="LRR 15"
FT   REPEAT          444..465
FT                   /note="LRR 16"
FT   REPEAT          467..489
FT                   /note="LRR 17"
FT   REPEAT          490..511
FT                   /note="LRR 18"
FT   REPEAT          513..535
FT                   /note="LRR 19"
FT   REPEAT          537..558
FT                   /note="LRR 20"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   577 AA;  64100 MW;  D5E04AFF5EF60BF2 CRC64;
     MSSSAGKDKE PKVSSGTKER EKEAKAVGPV KESKDKDLKS KVKDAKEGKR DPVGAQAGVA
     FSLDNTIKRA NPASGMRKKA SNAEVIKELS KCREENSTRL DLAKKSIHML PVSIKDLTQI
     TELYLYGNKL QSLPAEVGNL VNLVKLALSE NSLTSLPDSL DNLKKLCMLD LRHNKLREIP
     PVVYRLSSLT TLFLRFNRIT AVEKDLKMLP KLTMLSIREN KIKHLPAEIG ELCNLITLDV
     AHNQLEHLPK EIGNCTQITN LDLQHNELLD LPDTIGNLSS LSRLGLRYNR LSAVPRSLSK
     CSELDELNLE NNNISTLPEG LLSSLVKVNS LTLARNCFQS YPVGGPSQFS SIYSLNMEHN
     RINKIPFGIF SRAKVLSKLN MKDNQLTSLP LDFGTWTSMV ELNLATNQLT KIPEDVSGLV
     SIEVLILSNN LLKKLPHGIG NLRKLRELDL EENKLESLPN EIAYLKDLQK LVLTNNQLTT
     LPRGIGHLTN LTHLGLGENL LTHLPEEIGT LENLEELYLN DNPNLHSLPF ELALCSKLSI
     MSIENCPLSH LPPQIVAGGP SFIIQFLKMQ GPYRAMV