SHOT1_DANRE
ID SHOT1_DANRE Reviewed; 544 AA.
AC Q6P0R8; Q08C01; Q1RLX9;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Shootin-1 {ECO:0000250|UniProtKB:A0MZ67};
GN Name=shtn1 {ECO:0000250|UniProtKB:A0MZ66};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the generation of internal asymmetric signals
CC required for neuronal polarization and neurite outgrowth.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Perikaryon {ECO:0000250|UniProtKB:Q8K2Q9}. Cell
CC projection, axon {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection,
CC growth cone {ECO:0000250|UniProtKB:Q8K2Q9}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection, filopodium
CC {ECO:0000250|UniProtKB:A0MZ67}. Cell projection, lamellipodium
CC {ECO:0000250|UniProtKB:A0MZ67}.
CC -!- SIMILARITY: Belongs to the shootin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH65472.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI15237.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI24481.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC065472; AAH65472.1; ALT_INIT; mRNA.
DR EMBL; BC115236; AAI15237.1; ALT_INIT; mRNA.
DR EMBL; BC124480; AAI24481.1; ALT_INIT; mRNA.
DR RefSeq; NP_001185690.1; NM_001198761.1.
DR AlphaFoldDB; Q6P0R8; -.
DR SMR; Q6P0R8; -.
DR STRING; 7955.ENSDARP00000058026; -.
DR PaxDb; Q6P0R8; -.
DR Ensembl; ENSDART00000058027; ENSDARP00000058026; ENSDARG00000039697.
DR GeneID; 407656; -.
DR KEGG; dre:407656; -.
DR CTD; 57698; -.
DR ZFIN; ZDB-GENE-121127-1; shtn1.
DR eggNOG; ENOG502QVVT; Eukaryota.
DR GeneTree; ENSGT00510000048167; -.
DR HOGENOM; CLU_027649_1_1_1; -.
DR InParanoid; Q6P0R8; -.
DR OMA; NLMDAAI; -.
DR OrthoDB; 744654at2759; -.
DR PhylomeDB; Q6P0R8; -.
DR PRO; PR:Q6P0R8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 17.
DR Bgee; ENSDARG00000039697; Expressed in intestine and 17 other tissues.
DR GO; GO:0030424; C:axon; ISS:UniProtKB.
DR GO; GO:0044295; C:axonal growth cone; ISS:UniProtKB.
DR GO; GO:0031252; C:cell leading edge; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030175; C:filopodium; ISS:UniProtKB.
DR GO; GO:0030426; C:growth cone; ISS:UniProtKB.
DR GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
DR GO; GO:0005875; C:microtubule associated complex; ISS:UniProtKB.
DR GO; GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB.
DR GO; GO:0043204; C:perikaryon; ISS:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR GO; GO:0061573; P:actin filament bundle retrograde transport; ISS:UniProtKB.
DR GO; GO:0007409; P:axonogenesis; ISS:UniProtKB.
DR GO; GO:0032488; P:Cdc42 protein signal transduction; ISS:UniProtKB.
DR GO; GO:0060327; P:cytoplasmic actin-based contraction involved in cell motility; ISS:UniProtKB.
DR GO; GO:0061163; P:endoplasmic reticulum polarization; ISS:UniProtKB.
DR GO; GO:0038007; P:netrin-activated signaling pathway; ISS:UniProtKB.
DR GO; GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
DR GO; GO:0045773; P:positive regulation of axon extension; ISS:UniProtKB.
DR GO; GO:2001224; P:positive regulation of neuron migration; ISS:UniProtKB.
DR GO; GO:0048920; P:posterior lateral line neuromast primordium migration; IMP:ZFIN.
DR GO; GO:0007265; P:Ras protein signal transduction; ISS:UniProtKB.
DR GO; GO:2000114; P:regulation of establishment of cell polarity; ISS:UniProtKB.
DR GO; GO:0006930; P:substrate-dependent cell migration, cell extension; ISS:UniProtKB.
DR InterPro; IPR024849; Shootin-1.
DR PANTHER; PTHR46606; PTHR46606; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Coiled coil; Cytoplasm; Cytoskeleton;
KW Developmental protein; Reference proteome.
FT CHAIN 1..544
FT /note="Shootin-1"
FT /id="PRO_0000295744"
FT REGION 343..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 17..100
FT /evidence="ECO:0000255"
FT COILED 141..184
FT /evidence="ECO:0000255"
FT COILED 259..349
FT /evidence="ECO:0000255"
FT COILED 480..504
FT /evidence="ECO:0000255"
FT COMPBIAS 351..374
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 61682 MW; 06B7EFBFC2E82B29 CRC64;
MASKGKKNKV RTNSDLSNQV LLQYESLQKE HEKIKKECKK LQEERDEALR KLNEFESVSH
RVIEEVNSIQ ENLEIEKTCR ESVEALASKL NRQNLSLKRK SMLYMSRLAA DVVAEISIDD
EDDEDAHEEE AGVCSSSHCH IVITELRDKL EEILATKKQL MIDLETTREQ LSKTRQELLK
EKHDNTVLIA ETFQQKKLLG KYNRVSQYAL DEFESLQEDL KLERDLRSEA EKFAHEMLIE
QKKLKRQSQV LVQSISVGEA LQKALAEIST LTHTLEKQRL EHQQQVKGLE EQVNSSEVKK
QLTALQRQTD LLEEERKEWQ HKHTKAETEA KDLRFTVEEL KKKLQQVSNP PTAAPAPPPP
PPPPPPPPPP SSSSSNPLSS LLSILRKKKD VSTEIALVEK DSSEKSPEKD VRQQAVDEMM
LRIKKGVQLR PVSQTTNRVR PGPKEPTASN SAIQELQGIL NTVKRPGPSS SPGPRPPSPS
EKSELEKALQ RRREAVKSAK NNTNPSSVVD LTQIKQTRSE PGQNTGDQET LRHTTTTICT
EQLS
