SHOX2_MOUSE
ID SHOX2_MOUSE Reviewed; 331 AA.
AC P70390; P70369;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Short stature homeobox protein 2;
DE AltName: Full=Homeobox protein Og12X;
DE Short=OG-12;
DE AltName: Full=Paired family homeodomain protein Prx3;
GN Name=Shox2; Synonyms=Og12x, Prx3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryo;
RX PubMed=9371788; DOI=10.1073/pnas.94.24.12993;
RA van Schaick H.S.A., Smidt M.P., Rovescalli A.C., Luijten M.,
RA van der Kleij A.A.M., Asoh S., Kozak C.A., Nirenberg M.W., Burbach J.P.H.;
RT "Homeobox gene Prx3 expression in rodent brain and extraneural tissues.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:12993-12998(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 116-331 AND 235-331 (ISOFORMS 1
RP AND 2).
RC STRAIN=BALB/cJ; TISSUE=Embryo, and Liver;
RX PubMed=8855241; DOI=10.1073/pnas.93.20.10691;
RA Rovescalli A.C., Asoh S., Nirenberg M.W.;
RT "Cloning and characterization of four murine homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:10691-10696(1996).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=9466998; DOI=10.1093/hmg/7.3.415;
RA Semina E.V., Reiter R.S., Murray J.C.;
RT "A new human homeobox gene OG12X is a member of the most conserved homeobox
RT gene family and is expressed during heart development in mouse.";
RL Hum. Mol. Genet. 7:415-422(1998).
CC -!- FUNCTION: May be a growth regulator and have a role in specifying
CC neural systems involved in processing somatosensory information, as
CC well as in face and body structure formation. May also have a role in
CC heart development.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=OG12A, PRX3A;
CC IsoId=P70390-1; Sequence=Displayed;
CC Name=2; Synonyms=OG12B, PRX3B;
CC IsoId=P70390-2; Sequence=VSP_002289;
CC -!- TISSUE SPECIFICITY: Highly expressed in striated muscle followed by
CC liver, kidney, testis, brain, heart, lung and spleen.
CC -!- DEVELOPMENTAL STAGE: Expressed from 9 dpc to 16 dpc in the heart, otic
CC region, maxillary and mandibular components of the first branchial
CC arch, nasal processes, eyelid, midbrain, medulla oblongata, limbs,
CC dorsal root ganglia and genital tubercle. Also expressed in non-
CC neuronal structures around the oral cavity and in hip and shoulder
CC regions and in mesenchyme surrounding the vertebrae.
CC {ECO:0000269|PubMed:9466998}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC52831.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAC52832.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U66918; AAC52833.1; -; mRNA.
DR EMBL; U67055; AAC52834.1; -; mRNA.
DR EMBL; U65071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U65072; AAC52831.1; ALT_INIT; Genomic_DNA.
DR EMBL; U65072; AAC52832.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS17393.1; -. [P70390-1]
DR RefSeq; NP_001289286.1; NM_001302357.1. [P70390-2]
DR RefSeq; NP_001289287.1; NM_001302358.1.
DR RefSeq; NP_001289288.1; NM_001302359.1.
DR RefSeq; NP_038693.1; NM_013665.1. [P70390-1]
DR AlphaFoldDB; P70390; -.
DR SMR; P70390; -.
DR STRING; 10090.ENSMUSP00000029422; -.
DR iPTMnet; P70390; -.
DR PhosphoSitePlus; P70390; -.
DR PaxDb; P70390; -.
DR PeptideAtlas; P70390; -.
DR PRIDE; P70390; -.
DR ProteomicsDB; 257152; -. [P70390-1]
DR ProteomicsDB; 257153; -. [P70390-2]
DR Antibodypedia; 18427; 153 antibodies from 26 providers.
DR DNASU; 20429; -.
DR Ensembl; ENSMUST00000029422; ENSMUSP00000029422; ENSMUSG00000027833. [P70390-1]
DR GeneID; 20429; -.
DR KEGG; mmu:20429; -.
DR UCSC; uc008pld.2; mouse. [P70390-2]
DR UCSC; uc008ple.2; mouse. [P70390-1]
DR CTD; 6474; -.
DR MGI; MGI:1201673; Shox2.
DR VEuPathDB; HostDB:ENSMUSG00000027833; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000154287; -.
DR InParanoid; P70390; -.
DR OMA; MHGPERV; -.
DR OrthoDB; 1367513at2759; -.
DR PhylomeDB; P70390; -.
DR TreeFam; TF350757; -.
DR BRENDA; 1.11.1.25; 3474.
DR BioGRID-ORCS; 20429; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Prdx3; mouse.
DR PRO; PR:P70390; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; P70390; protein.
DR Bgee; ENSMUSG00000027833; Expressed in medial dorsal nucleus of thalamus and 174 other tissues.
DR ExpressionAtlas; P70390; baseline and differential.
DR Genevisible; P70390; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IC:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003209; P:cardiac atrium morphogenesis; IMP:MGI.
DR GO; GO:0060920; P:cardiac pacemaker cell differentiation; IMP:BHF-UCL.
DR GO; GO:0003213; P:cardiac right atrium morphogenesis; IMP:BHF-UCL.
DR GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IMP:MGI.
DR GO; GO:0002063; P:chondrocyte development; IMP:MGI.
DR GO; GO:0002062; P:chondrocyte differentiation; IMP:MGI.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IMP:MGI.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IMP:MGI.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.
DR GO; GO:0048598; P:embryonic morphogenesis; IMP:MGI.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IMP:MGI.
DR GO; GO:0003170; P:heart valve development; IMP:MGI.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IMP:MGI.
DR GO; GO:0060415; P:muscle tissue morphogenesis; IMP:BHF-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:BHF-UCL.
DR GO; GO:0001649; P:osteoblast differentiation; IMP:MGI.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IMP:BHF-UCL.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.
DR GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IMP:BHF-UCL.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:MGI.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IMP:MGI.
DR GO; GO:2000172; P:regulation of branching morphogenesis of a nerve; IMP:BHF-UCL.
DR GO; GO:0032330; P:regulation of chondrocyte differentiation; IMP:MGI.
DR GO; GO:0002027; P:regulation of heart rate; IMP:BHF-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060931; P:sinoatrial node cell development; IMP:BHF-UCL.
DR GO; GO:0003163; P:sinoatrial node development; IMP:BHF-UCL.
DR GO; GO:0003172; P:sinoatrial valve development; IMP:BHF-UCL.
DR GO; GO:0007224; P:smoothened signaling pathway; IMP:MGI.
DR GO; GO:0072089; P:stem cell proliferation; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR003654; OAR_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome.
FT CHAIN 1..331
FT /note="Short stature homeobox protein 2"
FT /id="PRO_0000049293"
FT DNA_BIND 140..199
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 26..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 313..326
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT COMPBIAS 97..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 235..246
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8855241,
FT ECO:0000303|PubMed:9371788"
FT /id="VSP_002289"
SQ SEQUENCE 331 AA; 34905 MW; D24D297E1D73A025 CRC64;
MEELTAFVSK SFDQKVKEKK EAITYREVLE SGPLRGAKEP GCVEPGRDDR SSPAVRAAGG
GGGAGGGGGG GGGGGGGAGG GGAGGGAGGG RSPVRELDMG AAERSREPGS PRLTEVSPEL
KDRKDDAKGM EDEGQTKIKQ RRSRTNFTLE QLNELERLFD ETHYPDAFMR EELSQRLGLS
EARVQVWFQN RRAKCRKQEN QLHKGVLIGA ASQFEACRVA PYVNVGALRM PFQQDSHCNV
TPLSFQVQAQ LQLDSAVAHA HHHLHPHLAA HAPYMMFPAP PFGLPLATLA ADSASAASVV
AAAAAAKTTS KNSSIADLRL KAKKHAAALG L
