BH019_ARATH
ID BH019_ARATH Reviewed; 295 AA.
AC Q1PF16; A0MEP4; O82397; Q8S3F2;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transcription factor bHLH19;
DE AltName: Full=Basic helix-loop-helix protein 19;
DE Short=AtbHLH19;
DE Short=bHLH 19;
DE AltName: Full=Transcription factor EN 26;
DE AltName: Full=bHLH transcription factor bHLH019;
GN Name=BHLH19; Synonyms=EN26; OrderedLocusNames=At2g22760; ORFNames=T30L20.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION BY COLD, GENE
RP FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q1PF16; Q9LNW3: AIP1; NbExp=3; IntAct=EBI-2367867, EBI-1573499;
CC Q1PF16; Q9ZT48: ATE1; NbExp=3; IntAct=EBI-2367867, EBI-25522944;
CC Q1PF16; F4IP06: SWC2; NbExp=3; IntAct=EBI-2367867, EBI-1537394;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and leaves.
CC {ECO:0000269|PubMed:12679534}.
CC -!- INDUCTION: By cold treatment. {ECO:0000269|PubMed:12679534}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC63587.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM15235.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ABK28508.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF488563; AAM10935.1; -; mRNA.
DR EMBL; AC005617; AAC63587.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC006340; AAM15235.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07351.1; -; Genomic_DNA.
DR EMBL; DQ446550; ABE65849.1; -; mRNA.
DR EMBL; DQ653016; ABK28508.1; ALT_SEQ; mRNA.
DR PIR; E84616; E84616.
DR RefSeq; NP_001323557.1; NM_001335823.1.
DR RefSeq; NP_179861.2; NM_127841.3.
DR AlphaFoldDB; Q1PF16; -.
DR SMR; Q1PF16; -.
DR BioGRID; 2159; 17.
DR IntAct; Q1PF16; 15.
DR STRING; 3702.AT2G22760.1; -.
DR iPTMnet; Q1PF16; -.
DR PaxDb; Q1PF16; -.
DR PRIDE; Q1PF16; -.
DR EnsemblPlants; AT2G22760.1; AT2G22760.1; AT2G22760.
DR GeneID; 816806; -.
DR Gramene; AT2G22760.1; AT2G22760.1; AT2G22760.
DR KEGG; ath:AT2G22760; -.
DR Araport; AT2G22760; -.
DR TAIR; locus:2062230; AT2G22760.
DR eggNOG; ENOG502QUSQ; Eukaryota.
DR HOGENOM; CLU_046481_0_1_1; -.
DR InParanoid; Q1PF16; -.
DR OMA; FNIYEEM; -.
DR OrthoDB; 1387598at2759; -.
DR PhylomeDB; Q1PF16; -.
DR PRO; PR:Q1PF16; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q1PF16; baseline and differential.
DR Genevisible; Q1PF16; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..295
FT /note="Transcription factor bHLH19"
FT /id="PRO_0000358733"
FT DOMAIN 115..164
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT CONFLICT 292
FT /note="L -> P (in Ref. 1; AAM10935)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 295 AA; 33787 MW; 76736E7B37FB99E8 CRC64;
MDEDFFLPDF SLVDIDFDFN IYEENNLSPD ESLSNSRRAD QSSKFDHQMH FECLREKPKA
AVKPMMKINN KQQLISFDFS SNVISSPAAE EIIMDKLVGR GTKRKTCSHG TRSPVLAKEH
VLAERKRREK LSEKFIALSA LLPGLKKADK VTILDDAISR MKQLQEQLRT LKEEKEATRQ
MESMILVKKS KVFFDEEPNL SCSPSVHIEF DQALPEIEAK ISQNDILIRI LCEKSKGCMI
NILNTIENFQ LRIENSIVLP FGDSTLDITV LAQMDKDFSM SILKDLVRNL RLAMV
