ID   SHQ1_BOVIN              Reviewed;         579 AA.
AC   Q3MHH1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protein SHQ1 homolog;
GN   Name=SHQ1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the quantitative accumulation of H/ACA
CC       ribonucleoproteins (RNPs), including telomerase, probably through the
CC       stabilization of DKC1, from the time of its synthesis until its
CC       association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with DKC1 alone, but not in the context of
CC       the core trimer composed of DKC1, NOP10 and NHP2, nor in the presence
CC       of NAF1. Does not interact with NAF1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus,
CC       nucleoplasm {ECO:0000250}. Note=May at least partially shuttle between
CC       cytosol and nucleoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHQ1 family. {ECO:0000305}.
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DR   EMBL; BC105240; AAI05241.1; -; mRNA.
DR   RefSeq; NP_001030221.1; NM_001035049.2.
DR   AlphaFoldDB; Q3MHH1; -.
DR   SMR; Q3MHH1; -.
DR   STRING; 9913.ENSBTAP00000007154; -.
DR   PaxDb; Q3MHH1; -.
DR   PRIDE; Q3MHH1; -.
DR   Ensembl; ENSBTAT00000007154; ENSBTAP00000007154; ENSBTAG00000005436.
DR   GeneID; 507486; -.
DR   KEGG; bta:507486; -.
DR   CTD; 55164; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005436; -.
DR   VGNC; VGNC:34607; SHQ1.
DR   eggNOG; KOG3247; Eukaryota.
DR   GeneTree; ENSGT00390000007605; -.
DR   HOGENOM; CLU_030217_0_0_1; -.
DR   InParanoid; Q3MHH1; -.
DR   OMA; NDWQLPQ; -.
DR   OrthoDB; 879404at2759; -.
DR   TreeFam; TF106118; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000005436; Expressed in adenohypophysis and 104 other tissues.
DR   ExpressionAtlas; Q3MHH1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0000493; P:box H/ACA snoRNP assembly; IBA:GO_Central.
DR   GO; GO:2000233; P:negative regulation of rRNA processing; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0022618; P:ribonucleoprotein complex assembly; ISS:UniProtKB.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR039742; Shq1.
DR   InterPro; IPR007009; Shq1_dom.
DR   PANTHER; PTHR12967; PTHR12967; 1.
DR   Pfam; PF04925; SHQ1; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS51203; CS; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..579
FT                   /note="Protein SHQ1 homolog"
FT                   /id="PRO_0000302821"
FT   DOMAIN          1..89
FT                   /note="CS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT   REGION          438..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          550..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..465
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..482
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        550..570
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  65067 MW;  85B35EFB320802B7 CRC64;
     MLTPAFDLSQ DPDFLTVAIR VPYARVSEFD VYFEGVDFKF YAKPYFLRLT LPGRIVENGN
     EQGSYDADKG IFTIRLPKET PGQHFEGLNM LTALLAPRKS RTAKPLVEEI GASEVSEGGV
     EDDDDEFDWE IEQSPYEEVP ESALNPNCRY GFGNLRSGVF QRLQDELSDV IDIKDPDFTS
     AAERRQKRLA AELAKFDPDH YLADFMEDEA VKQVLEYNPW WSDLYSEMMT SLGKSQEEEN
     LAALVSFSEE EKYQLRKFVN KSYLLDKKAH RQVYYSLIDI LLAYCYETRV TEGERNVESA
     WNIRKLSPTL CWFETWTNVH EILVSFGRRV LCYPLYRHFK LVMKTYRDTI KILQLGKSAV
     LKCLLDIHKI FQENDPAYIL NDLYISDYCV WIQKAKSKKL AALAEALKKA SLTKAQLGLE
     LEELEAAAFL VQEEEATSKA GVHSTSRQQT PSSSSETSGS EESEGSASLE TEESDSEQEE
     PGGGESETGH SLLGPFVEES SMALLLNDGG MCRSTTFLGS DGGRGQPLAS PGAPIAFGPL
     IQELGEQLET SVQISEPKDS AAGQQDSVLE RESRQTPED