SHQ1_DROME
ID SHQ1_DROME Reviewed; 608 AA.
AC Q9VI74; Q8MSE2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Protein SHQ1 homolog;
GN ORFNames=CG10055;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Ovary;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Required for the quantitative accumulation of H/ACA
CC ribonucleoproteins (RNPs). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHQ1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM50735.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF54051.1; -; Genomic_DNA.
DR EMBL; AY118875; AAM50735.1; ALT_SEQ; mRNA.
DR RefSeq; NP_649703.1; NM_141446.2.
DR AlphaFoldDB; Q9VI74; -.
DR SMR; Q9VI74; -.
DR BioGRID; 66057; 1.
DR STRING; 7227.FBpp0081123; -.
DR PaxDb; Q9VI74; -.
DR DNASU; 40862; -.
DR EnsemblMetazoa; FBtr0081605; FBpp0081123; FBgn0037482.
DR GeneID; 40862; -.
DR KEGG; dme:Dmel_CG10055; -.
DR UCSC; CG10055-RA; d. melanogaster.
DR FlyBase; FBgn0037482; CG10055.
DR VEuPathDB; VectorBase:FBgn0037482; -.
DR eggNOG; KOG3247; Eukaryota.
DR GeneTree; ENSGT00390000007605; -.
DR HOGENOM; CLU_449237_0_0_1; -.
DR InParanoid; Q9VI74; -.
DR OMA; MTQEQAH; -.
DR OrthoDB; 879404at2759; -.
DR PhylomeDB; Q9VI74; -.
DR Reactome; R-DME-171319; Telomere Extension By Telomerase.
DR BioGRID-ORCS; 40862; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 40862; -.
DR PRO; PR:Q9VI74; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037482; Expressed in testis and 23 other tissues.
DR ExpressionAtlas; Q9VI74; baseline and differential.
DR Genevisible; Q9VI74; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0000493; P:box H/ACA snoRNP assembly; IBA:GO_Central.
DR GO; GO:0022618; P:ribonucleoprotein complex assembly; ISS:UniProtKB.
DR InterPro; IPR039742; Shq1.
DR InterPro; IPR007009; Shq1_dom.
DR PANTHER; PTHR12967; PTHR12967; 1.
DR Pfam; PF04925; SHQ1; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..608
FT /note="Protein SHQ1 homolog"
FT /id="PRO_0000302827"
FT REGION 487..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..522
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..581
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 69146 MW; 035736E5F2567014 CRC64;
MLNGQIAHSY LENSCTLIIP RPPVLNQSSK SAQPAAAAAA SSSAGEEFGQ EAGSGLAEAE
ALHVDRIRNC DIFVDAHDLY FYADVKLYKF HSRRTFDLRE LKTLLIKFNT TENHYQICLR
CLPLTAGAQE GPGGERGGGG GTGDAAKQWN SRKEYIAAFL HLPTLSANLP DKQPLVQEWK
LKRITDQCQL QLDDHERTYK LTNNFGYGYA SEYSGPLDLS ELDRATCRVS EPHRMSPIQR
RQERVVDEMK RFSREQYKIN FVELQVPSGH QNPLRYKPKI YETSMTQEQA HLLHNISRMQ
TREQQPCDVF RQNEIDCGLI SILLAICYDV RTTNNEPTCE SGWTRSILCP LYCYFEQFDN
YRDVLVAFLR RMITYPLYRN FELGRQCVRD AIEVLKGGRN WLINQLLLTH QQFASSDPSR
DSFNNYYLED YIRYVTSPSA CSDEHMRLLA RNLKNVLMDV NKQHLGLGVT EIETELIKEL
MQEMRIDAGS QGSSPQQQHG DDDLDLDNDT SGQEDETTTD DESVITDSFY SVDMDMRLIE
NEIVYEDDEE DEDDDEDGDD DEDGDGDEDE DEDEDEDDSS SSTTTSSEAE GNSVIEQCSN
SETAASTT
