SHQ1_MOUSE
ID SHQ1_MOUSE Reviewed; 569 AA.
AC Q7TMX5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein SHQ1 homolog;
GN Name=Shq1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6NCr; TISSUE=Hematopoietic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for the quantitative accumulation of H/ACA
CC ribonucleoproteins (RNPs), including telomerase, probably through the
CC stabilization of DKC1, from the time of its synthesis until its
CC association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.
CC {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with DKC1 alone, but not in the context of
CC the core trimer composed of DKC1, NOP10 and NHP2, nor in the presence
CC of NAF1. Does not interact with NAF1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus,
CC nucleoplasm {ECO:0000250}. Note=May at least partially shuttle between
CC cytosol and nucleoplasm. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7TMX5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TMX5-2; Sequence=VSP_027961;
CC -!- SIMILARITY: Belongs to the SHQ1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK012978; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC052657; AAH52657.1; -; mRNA.
DR CCDS; CCDS39580.2; -. [Q7TMX5-1]
DR RefSeq; NP_853621.2; NM_181590.5. [Q7TMX5-1]
DR RefSeq; XP_006506732.1; XM_006506669.3. [Q7TMX5-2]
DR AlphaFoldDB; Q7TMX5; -.
DR SMR; Q7TMX5; -.
DR STRING; 10090.ENSMUSP00000108938; -.
DR iPTMnet; Q7TMX5; -.
DR PhosphoSitePlus; Q7TMX5; -.
DR EPD; Q7TMX5; -.
DR MaxQB; Q7TMX5; -.
DR PaxDb; Q7TMX5; -.
DR PeptideAtlas; Q7TMX5; -.
DR PRIDE; Q7TMX5; -.
DR ProteomicsDB; 255417; -. [Q7TMX5-1]
DR ProteomicsDB; 255418; -. [Q7TMX5-2]
DR Antibodypedia; 51842; 98 antibodies from 21 providers.
DR Ensembl; ENSMUST00000089245; ENSMUSP00000086656; ENSMUSG00000035378. [Q7TMX5-2]
DR Ensembl; ENSMUST00000113312; ENSMUSP00000108938; ENSMUSG00000035378. [Q7TMX5-1]
DR Ensembl; ENSMUST00000170667; ENSMUSP00000127797; ENSMUSG00000035378. [Q7TMX5-1]
DR GeneID; 72171; -.
DR KEGG; mmu:72171; -.
DR UCSC; uc009dby.2; mouse. [Q7TMX5-2]
DR UCSC; uc009dbz.2; mouse. [Q7TMX5-1]
DR CTD; 55164; -.
DR MGI; MGI:1919421; Shq1.
DR VEuPathDB; HostDB:ENSMUSG00000035378; -.
DR eggNOG; KOG3247; Eukaryota.
DR GeneTree; ENSGT00390000007605; -.
DR HOGENOM; CLU_030217_0_0_1; -.
DR InParanoid; Q7TMX5; -.
DR OMA; NDWQLPQ; -.
DR OrthoDB; 879404at2759; -.
DR PhylomeDB; Q7TMX5; -.
DR TreeFam; TF106118; -.
DR Reactome; R-MMU-171319; Telomere Extension By Telomerase.
DR BioGRID-ORCS; 72171; 23 hits in 58 CRISPR screens.
DR ChiTaRS; Shq1; mouse.
DR PRO; PR:Q7TMX5; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7TMX5; protein.
DR Bgee; ENSMUSG00000035378; Expressed in dorsal pancreas and 178 other tissues.
DR Genevisible; Q7TMX5; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0000493; P:box H/ACA snoRNP assembly; IBA:GO_Central.
DR GO; GO:2000233; P:negative regulation of rRNA processing; ISO:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0022618; P:ribonucleoprotein complex assembly; ISS:UniProtKB.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR039742; Shq1.
DR InterPro; IPR007009; Shq1_dom.
DR PANTHER; PTHR12967; PTHR12967; 1.
DR Pfam; PF04925; SHQ1; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS51203; CS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..569
FT /note="Protein SHQ1 homolog"
FT /id="PRO_0000302823"
FT DOMAIN 1..89
FT /note="CS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT REGION 439..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 244..354
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027961"
FT CONFLICT 87
FT /note="G -> E (in Ref. 2; AAH52657)"
FT /evidence="ECO:0000305"
FT CONFLICT 528
FT /note="A -> T (in Ref. 2; AAH52657)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 569 AA; 63458 MW; 6A174E1DD317B84E CRC64;
MLTPAFELTQ DCDFLTVAIR VPHARASEFD VYFEGVDFKF YAKPYFLRLT LPGRIVENGS
EQGTYDADKG IFTIRLPKET PGQHFEGLNM LTALLAPRKS RSAKPLVEEI GASGVAEEGA
DDEDEEFDWE IEQTPYEEVS ESTLQSQCHY GFGNLRAGVV QRLQDELSEV IDIKDPDFTP
VTERRQKRLA AELAKFDPDH YLADFFEDEA VEQILKYSPW WNDAHAEMVA SLGKNQEQGD
SAALVSFSEE EKYQLRKFVN KSYLLDKTAH RQVYYGLVDI LLAYCYEVRV TEGEHSVESA
WTIRKLSPTL CWFETWTDVH EILVSFGRRV LCYPLYRHFK LVLKAYRDTI KILQLGKSAV
LKCLLDVHKV FQENDPAYIL NDLYISDYCV WIQKAKSKKL AALTEALKAV SLSKAQLGLE
LPELEAAALL VQEEEGAGRA AQCNPSHQAP HSSPEPSDSD STSSSGTEDS ASEQEEPAGT
QPSLLTSLQA PLLEEDSALI IRESGLCRNM ASQGCEVSQG QPLASARAPL IEELGDALKM
LRVSTPHGVS AGSHGSVEDA EERGQVPCD
