BH023_ARATH
ID BH023_ARATH Reviewed; 413 AA.
AC Q9SVU6; Q5XEY8;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transcription factor bHLH23;
DE AltName: Full=Basic helix-loop-helix protein 23;
DE Short=AtbHLH23;
DE Short=bHLH 23;
DE AltName: Full=Transcription factor EN 107;
DE AltName: Full=bHLH transcription factor bHLH023;
GN Name=BHLH23; Synonyms=EN107; OrderedLocusNames=At4g28790;
GN ORFNames=F16A16.100;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9SVU6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9SVU6-2; Sequence=VSP_036077, VSP_036078;
CC Name=3;
CC IsoId=Q9SVU6-3; Sequence=VSP_036079, VSP_036080;
CC -!- TISSUE SPECIFICITY: Expressed constitutively in leaves, stems, and
CC flowers. {ECO:0000269|PubMed:12679534}.
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DR EMBL; AL035353; CAA22973.1; -; Genomic_DNA.
DR EMBL; AL161573; CAB81467.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85544.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85545.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66994.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66996.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66999.1; -; Genomic_DNA.
DR EMBL; BT015828; AAU94391.1; -; mRNA.
DR EMBL; BT020214; AAV59280.1; -; mRNA.
DR PIR; T04520; T04520.
DR RefSeq; NP_001320083.1; NM_001341933.1. [Q9SVU6-1]
DR RefSeq; NP_001328852.1; NM_001341938.1. [Q9SVU6-2]
DR RefSeq; NP_001328854.1; NM_001341936.1. [Q9SVU6-2]
DR RefSeq; NP_001328857.1; NM_001341939.1. [Q9SVU6-2]
DR RefSeq; NP_974634.1; NM_202905.1. [Q9SVU6-3]
DR AlphaFoldDB; Q9SVU6; -.
DR SMR; Q9SVU6; -.
DR STRING; 3702.AT4G28790.1; -.
DR PaxDb; Q9SVU6; -.
DR PRIDE; Q9SVU6; -.
DR EnsemblPlants; AT4G28790.1; AT4G28790.1; AT4G28790. [Q9SVU6-1]
DR EnsemblPlants; AT4G28790.2; AT4G28790.2; AT4G28790. [Q9SVU6-3]
DR EnsemblPlants; AT4G28790.5; AT4G28790.5; AT4G28790. [Q9SVU6-2]
DR EnsemblPlants; AT4G28790.7; AT4G28790.7; AT4G28790. [Q9SVU6-2]
DR EnsemblPlants; AT4G28790.8; AT4G28790.8; AT4G28790. [Q9SVU6-2]
DR GeneID; 829000; -.
DR Gramene; AT4G28790.1; AT4G28790.1; AT4G28790. [Q9SVU6-1]
DR Gramene; AT4G28790.2; AT4G28790.2; AT4G28790. [Q9SVU6-3]
DR Gramene; AT4G28790.5; AT4G28790.5; AT4G28790. [Q9SVU6-2]
DR Gramene; AT4G28790.7; AT4G28790.7; AT4G28790. [Q9SVU6-2]
DR Gramene; AT4G28790.8; AT4G28790.8; AT4G28790. [Q9SVU6-2]
DR KEGG; ath:AT4G28790; -.
DR Araport; AT4G28790; -.
DR TAIR; locus:2117773; AT4G28790.
DR eggNOG; ENOG502QR6A; Eukaryota.
DR InParanoid; Q9SVU6; -.
DR OMA; MHSISER; -.
DR PhylomeDB; Q9SVU6; -.
DR PRO; PR:Q9SVU6; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SVU6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR031066; bHLH_ALC-like_plant.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR45855; PTHR45855; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..413
FT /note="Transcription factor bHLH23"
FT /id="PRO_0000358735"
FT DOMAIN 277..326
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 40..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 186
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8GZM7"
FT MOD_RES 191
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8GZM7"
FT VAR_SEQ 276..283
FT /note="SRAAIMHK -> DGDKRLTR (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_036077"
FT VAR_SEQ 284..413
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_036078"
FT VAR_SEQ 332..340
FT /note="MFSMGHVMI -> GKHLRIFRS (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_036079"
FT VAR_SEQ 341..413
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_036080"
SQ SEQUENCE 413 AA; 46070 MW; C6EB75EA5578AD4F CRC64;
MTWKPKMLIL SHDLISPEKY IMGEDDIVEL LGKSSQVVTS SQTQTPSCDP PLILRGSGSG
DGEGNGPLPQ PPPPLYHQQS LFIQEDEMAS WLHQPNRQDY LYSQLLYSGV ASTHPQSLAS
LEPPPPPRAQ YILAADRPTG HILAERRAEN FMNISRQRGN IFLGGVEAVP SNSTLLSSAT
ESIPATHGTE SRATVTGGVS RTFAVPGLGP RGKAVAIETA GTQSWGLCKA ETEPVQRQPA
TETDITDERK RKTREETNVE NQGTEEARDS TSSKRSRAAI MHKLSERRRR QKINEMMKAL
QELLPRCTKT DRSSMLDDVI EYVKSLQSQI QMFSMGHVMI PPMMYAGNIQ QQYMPHMAMG
MNRPPAFIPF PRQAHMAEGV GPVDLFRENE ETEQETMSLL LREDKRTKQK MFS
