BH025_ARATH
ID BH025_ARATH Reviewed; 328 AA.
AC Q9T072; Q8S3F0;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Transcription factor bHLH25;
DE AltName: Full=Basic helix-loop-helix protein 25;
DE Short=AtbHLH25;
DE Short=bHLH 25;
DE AltName: Full=Transcription factor EN 29;
DE AltName: Full=bHLH transcription factor bHLH025;
GN Name=BHLH25; Synonyms=EN29; OrderedLocusNames=At4g37850;
GN ORFNames=T28I19.130;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-328, TISSUE SPECIFICITY, INDUCTION, GENE
RP FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in flowers.
CC {ECO:0000269|PubMed:12679534}.
CC -!- INDUCTION: By ethylene (ACC) and jasmonic acid (JA) treatments.
CC {ECO:0000269|PubMed:12679534}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB38933.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80450.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL035709; CAB38933.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161592; CAB80450.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86845.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67978.1; -; Genomic_DNA.
DR EMBL; AF488567; AAM10937.1; -; mRNA.
DR PIR; T06032; T06032.
DR RefSeq; NP_001329767.1; NM_001342458.1.
DR RefSeq; NP_195498.3; NM_119946.4.
DR AlphaFoldDB; Q9T072; -.
DR SMR; Q9T072; -.
DR BioGRID; 15222; 7.
DR IntAct; Q9T072; 6.
DR STRING; 3702.AT4G37850.1; -.
DR PaxDb; Q9T072; -.
DR PRIDE; Q9T072; -.
DR ProteomicsDB; 240431; -.
DR EnsemblPlants; AT4G37850.1; AT4G37850.1; AT4G37850.
DR EnsemblPlants; AT4G37850.2; AT4G37850.2; AT4G37850.
DR GeneID; 829941; -.
DR Gramene; AT4G37850.1; AT4G37850.1; AT4G37850.
DR Gramene; AT4G37850.2; AT4G37850.2; AT4G37850.
DR KEGG; ath:AT4G37850; -.
DR Araport; AT4G37850; -.
DR TAIR; locus:2137574; AT4G37850.
DR eggNOG; ENOG502QWBY; Eukaryota.
DR HOGENOM; CLU_046481_0_1_1; -.
DR InParanoid; Q9T072; -.
DR OMA; NDMEHEY; -.
DR OrthoDB; 1387598at2759; -.
DR PhylomeDB; Q9T072; -.
DR PRO; PR:Q9T072; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9T072; baseline and differential.
DR Genevisible; Q9T072; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..328
FT /note="Transcription factor bHLH25"
FT /id="PRO_0000358736"
FT DOMAIN 148..197
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 125..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 37703 MW; 277EFACA50FBD376 CRC64;
MSILSTRWFS EQEIEENSII QQFHMNSIVG EVQEAQYIFP HSFTTNNDPS YDDLIEMKPP
KILETTYISP SSHLPPNSKP HHIHRHSSSR ILSFEDYGSN DMEHEYSPTY LNSIFSPKLE
AQVQPHQKSD EFNRKGTKRA QPFSRNQSNA QDHIIAERKR REKLTQRFVA LSALVPGLKK
MDKASVLGDA LKHIKYLQER VGELEEQKKE RRLESMVLVK KSKLILDDNN QSFSSSCEDG
FSDLDLPEIE VRFSDEDVLI KILCEKQKGH LAKIMAEIEK LHILITNSSV LNFGPTLDIT
IIAKKESDFD MTLMDVVKSL RSALSNFI
