BH027_ARATH
ID BH027_ARATH Reviewed; 263 AA.
AC Q700E3; B3H6F5; Q67XZ4; Q8GYC3;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Transcription factor bHLH27;
DE AltName: Full=Basic helix-loop-helix protein 27;
DE Short=AtbHLH27;
DE Short=bHLH 27;
DE AltName: Full=Transcription factor EN 42;
DE AltName: Full=bHLH transcription factor bHLH027;
GN Name=BHLH27; Synonyms=EN42; OrderedLocusNames=At4g29930;
GN ORFNames=F27B13.170;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=15208423; DOI=10.1104/pp.104.042176;
RA Gong W., Shen Y.-P., Ma L.-G., Pan Y., Du Y.-L., Wang D.-H., Yang J.-Y.,
RA Hu L.-D., Liu X.-F., Dong C.-X., Ma L., Chen Y.-H., Yang X.-Y., Gao Y.,
RA Zhu D., Tan X., Mu J.-Y., Zhang D.-B., Liu Y.-L., Dinesh-Kumar S.P., Li Y.,
RA Wang X.-P., Gu H.-Y., Qu L.-J., Bai S.-N., Lu Y.-T., Li J.-Y., Zhao J.-D.,
RA Zuo J., Huang H., Deng X.-W., Zhu Y.-X.;
RT "Genome-wide ORFeome cloning and analysis of Arabidopsis transcription
RT factor genes.";
RL Plant Physiol. 135:773-782(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 54-254 (ISOFORM 2), TISSUE SPECIFICITY, GENE
RP FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [8]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [9]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q700E3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q700E3-2; Sequence=VSP_036083;
CC Name=3;
CC IsoId=Q700E3-3; Sequence=VSP_036081, VSP_036083;
CC Name=4;
CC IsoId=Q700E3-4; Sequence=VSP_036082;
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems,
CC and flowers. {ECO:0000269|PubMed:12679534}.
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DR EMBL; AL161575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002687; AEE85694.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85695.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85696.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85697.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67230.1; -; Genomic_DNA.
DR EMBL; AK117730; BAC42379.1; -; mRNA.
DR EMBL; BT005869; AAO64804.1; -; mRNA.
DR EMBL; AY568654; AAS79544.1; -; mRNA.
DR EMBL; AJ630482; CAG25855.1; -; mRNA.
DR EMBL; AK176201; BAD43964.1; -; mRNA.
DR EMBL; AK176276; BAD44039.1; -; mRNA.
DR EMBL; AK176674; BAD44437.1; -; mRNA.
DR EMBL; AK222212; BAD95372.1; -; mRNA.
DR EMBL; AK228201; BAF00155.1; -; mRNA.
DR EMBL; AF488569; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001031752.1; NM_001036675.1. [Q700E3-3]
DR RefSeq; NP_001078471.1; NM_001085002.2. [Q700E3-1]
DR RefSeq; NP_001119080.1; NM_001125608.1. [Q700E3-4]
DR RefSeq; NP_001329072.1; NM_001341985.1. [Q700E3-1]
DR RefSeq; NP_194722.2; NM_119139.3. [Q700E3-2]
DR AlphaFoldDB; Q700E3; -.
DR SMR; Q700E3; -.
DR BioGRID; 14403; 21.
DR IntAct; Q700E3; 20.
DR STRING; 3702.AT4G29930.3; -.
DR PaxDb; Q700E3; -.
DR PRIDE; Q700E3; -.
DR EnsemblPlants; AT4G29930.1; AT4G29930.1; AT4G29930. [Q700E3-2]
DR EnsemblPlants; AT4G29930.2; AT4G29930.2; AT4G29930. [Q700E3-3]
DR EnsemblPlants; AT4G29930.3; AT4G29930.3; AT4G29930. [Q700E3-1]
DR EnsemblPlants; AT4G29930.4; AT4G29930.4; AT4G29930. [Q700E3-4]
DR EnsemblPlants; AT4G29930.7; AT4G29930.7; AT4G29930. [Q700E3-1]
DR GeneID; 829116; -.
DR Gramene; AT4G29930.1; AT4G29930.1; AT4G29930. [Q700E3-2]
DR Gramene; AT4G29930.2; AT4G29930.2; AT4G29930. [Q700E3-3]
DR Gramene; AT4G29930.3; AT4G29930.3; AT4G29930. [Q700E3-1]
DR Gramene; AT4G29930.4; AT4G29930.4; AT4G29930. [Q700E3-4]
DR Gramene; AT4G29930.7; AT4G29930.7; AT4G29930. [Q700E3-1]
DR KEGG; ath:AT4G29930; -.
DR Araport; AT4G29930; -.
DR TAIR; locus:2123954; AT4G29930.
DR eggNOG; ENOG502QWG4; Eukaryota.
DR InParanoid; Q700E3; -.
DR OMA; CRAMEAL; -.
DR OrthoDB; 1160318at2759; -.
DR PhylomeDB; Q700E3; -.
DR PRO; PR:Q700E3; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q700E3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..263
FT /note="Transcription factor bHLH27"
FT /id="PRO_0000358737"
FT DOMAIN 50..99
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 32..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 124..152
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.6"
FT /id="VSP_036081"
FT VAR_SEQ 169..263
FT /note="MKVTWMGEKTVVVCITCSKKRETMVQLCKVLESLNLNILTTNFSSFTSRLST
FT TLFLQVTLSLSPSLISLFGNVITSTNYKILNASREYCTCLVLV -> VRTMHYLAVHSK
FT LPFF (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_036082"
FT VAR_SEQ 226..263
FT /note="VTLSLSPSLISLFGNVITSTNYKILNASREYCTCLVLV -> ADEEESSAVE
FT AKIQMAIAAYNDPNCLINF (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:11910074,
FT ECO:0000303|PubMed:12679534, ECO:0000303|PubMed:14593172,
FT ECO:0000303|Ref.6"
FT /id="VSP_036083"
FT CONFLICT 139
FT /note="F -> I (in Ref. 7; AF488569)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 263 AA; 30280 MW; C0D7FA630D6F771D CRC64;
MEDLDHEYKN YWETTMFFQN QELEFDSWPM EEAFSGSGES SSPDGAATSP ASSKNVVSER
NRRQKLNQRL FALRSVVPNI SKLDKASVIK DSIDYMQELI DQEKTLEAEI RELESRSTLL
ENPVRDYDCN FAETHLQDFS DNNDMRSKKF KQMDYSTRVQ HYPIEVLEMK VTWMGEKTVV
VCITCSKKRE TMVQLCKVLE SLNLNILTTN FSSFTSRLST TLFLQVTLSL SPSLISLFGN
VITSTNYKIL NASREYCTCL VLV