ID   SHSA2_BOVIN             Reviewed;         289 AA.
AC   A6QPA0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein shisa-2 homolog;
DE   AltName: Full=Transmembrane protein 46;
DE   Flags: Precursor;
GN   Name=SHISA2; Synonyms=TMEM46;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in the maturation of presomitic
CC       mesoderm cells by individual attenuation of both FGF and WNT signaling.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; BC149221; AAI49222.1; -; mRNA.
DR   RefSeq; NP_001094735.1; NM_001101265.1.
DR   AlphaFoldDB; A6QPA0; -.
DR   SMR; A6QPA0; -.
DR   STRING; 9913.ENSBTAP00000024243; -.
DR   PaxDb; A6QPA0; -.
DR   Ensembl; ENSBTAT00000024243; ENSBTAP00000024243; ENSBTAG00000018214.
DR   GeneID; 617336; -.
DR   KEGG; bta:617336; -.
DR   CTD; 387914; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018214; -.
DR   VGNC; VGNC:34598; SHISA2.
DR   eggNOG; ENOG502QWT7; Eukaryota.
DR   GeneTree; ENSGT00940000157443; -.
DR   HOGENOM; CLU_085916_0_0_1; -.
DR   InParanoid; A6QPA0; -.
DR   OMA; YAHPVSP; -.
DR   OrthoDB; 1325567at2759; -.
DR   TreeFam; TF330800; -.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000018214; Expressed in biceps femoris and 90 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IBA:GO_Central.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395; PTHR31395; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..289
FT                   /note="Protein shisa-2 homolog"
FT                   /id="PRO_0000330023"
FT   TOPO_DOM        28..104
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..289
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          81..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          162..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   289 AA;  30510 MW;  4FC3A5DFE646BAFE CRC64;
     MWAGCHPDAA SLLRLLLAAL LAAGALASGE YCHGWLDAQG VWRIGFQCPE RFDGGDATIC
     CGSCALRYCC SSADARLDQG GCDNDRQQGA GEPGRADKDG PDGSAVPIYV PFLIVGSVFV
     AFIVLGSLVA ACCCRCLRPK QEPQLSRAPG GPRLVETIPM IPSASTSRGS SSRQSSTAAS
     SSSSANSGAR APPTRSQTNC CLPEGTMNNV YVNMPTNFSV LNCQQATQIV PHQGQYLHPP
     FVGYTVQPDS VPLTPVPPFL DGLQTGYRQL QAPFPHTNSE QKMYPAVTV