SHSA3_HUMAN
ID SHSA3_HUMAN Reviewed; 238 AA.
AC A0PJX4; A0PJX3; Q96EQ5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Protein shisa-3 homolog;
DE Flags: Precursor;
GN Name=SHISA3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-13.
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays an essential role in the maturation of presomitic
CC mesoderm cells by individual attenuation of both FGF and WNT signaling.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC A0PJX4; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-10171518, EBI-12109402;
CC A0PJX4; O75508: CLDN11; NbExp=3; IntAct=EBI-10171518, EBI-12820543;
CC A0PJX4; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-10171518, EBI-2807956;
CC A0PJX4; P21145: MAL; NbExp=3; IntAct=EBI-10171518, EBI-3932027;
CC A0PJX4; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10171518, EBI-16439278;
CC A0PJX4; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-10171518, EBI-302345;
CC A0PJX4; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-10171518, EBI-348587;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250,
CC ECO:0000250|UniProtKB:Q7T0Z7}; Single-pass type I membrane protein
CC {ECO:0000250|UniProtKB:Q7T0Z7}.
CC -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR EMBL; CH471069; EAW93002.1; -; Genomic_DNA.
DR EMBL; BC012029; AAH12029.1; -; mRNA.
DR EMBL; BC127690; AAI27691.1; -; mRNA.
DR EMBL; BC127691; AAI27692.1; -; mRNA.
DR CCDS; CCDS33979.1; -.
DR RefSeq; NP_001073974.1; NM_001080505.1.
DR AlphaFoldDB; A0PJX4; -.
DR SMR; A0PJX4; -.
DR BioGRID; 127452; 36.
DR IntAct; A0PJX4; 8.
DR STRING; 9606.ENSP00000326445; -.
DR iPTMnet; A0PJX4; -.
DR PhosphoSitePlus; A0PJX4; -.
DR BioMuta; SHISA3; -.
DR MassIVE; A0PJX4; -.
DR PaxDb; A0PJX4; -.
DR PeptideAtlas; A0PJX4; -.
DR PRIDE; A0PJX4; -.
DR ProteomicsDB; 68; -.
DR Antibodypedia; 56214; 70 antibodies from 21 providers.
DR DNASU; 152573; -.
DR Ensembl; ENST00000319234.5; ENSP00000326445.4; ENSG00000178343.5.
DR GeneID; 152573; -.
DR KEGG; hsa:152573; -.
DR MANE-Select; ENST00000319234.5; ENSP00000326445.4; NM_001080505.3; NP_001073974.1.
DR UCSC; uc003gwp.3; human.
DR CTD; 152573; -.
DR DisGeNET; 152573; -.
DR GeneCards; SHISA3; -.
DR HGNC; HGNC:25159; SHISA3.
DR HPA; ENSG00000178343; Tissue enhanced (heart muscle, kidney).
DR MIM; 617325; gene.
DR neXtProt; NX_A0PJX4; -.
DR OpenTargets; ENSG00000178343; -.
DR PharmGKB; PA162403293; -.
DR VEuPathDB; HostDB:ENSG00000178343; -.
DR eggNOG; ENOG502RY5T; Eukaryota.
DR GeneTree; ENSGT00940000161360; -.
DR HOGENOM; CLU_085916_1_0_1; -.
DR InParanoid; A0PJX4; -.
DR OMA; YTSGCLQ; -.
DR OrthoDB; 1325567at2759; -.
DR PhylomeDB; A0PJX4; -.
DR TreeFam; TF330800; -.
DR PathwayCommons; A0PJX4; -.
DR SignaLink; A0PJX4; -.
DR BioGRID-ORCS; 152573; 6 hits in 1059 CRISPR screens.
DR GenomeRNAi; 152573; -.
DR Pharos; A0PJX4; Tbio.
DR PRO; PR:A0PJX4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; A0PJX4; protein.
DR Bgee; ENSG00000178343; Expressed in germinal epithelium of ovary and 117 other tissues.
DR Genevisible; A0PJX4; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31395; PTHR31395; 1.
DR Pfam; PF13908; Shisa; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Endoplasmic reticulum; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..238
FT /note="Protein shisa-3 homolog"
FT /id="PRO_0000330025"
FT TOPO_DOM 22..98
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 151..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 13
FT /note="W -> C (in dbSNP:rs11733156)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_042687"
FT CONFLICT 95
FT /note="V -> G (in Ref. 2; AAH12029)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 238 AA; 25832 MW; 8469E3758F61D22C CRC64;
MRALLALCLL LGWLRWGPAG AQQSGEYCHG WVDVQGNYHE GFQCPEDFDT LDATICCGSC
ALRYCCAAAD ARLEQGGCTN DRRELEHPGI TAQPVYVPFL IVGSIFIAFI ILGSVVAIYC
CTCLRPKEPS QQPIRFSLRS YQTETLPMIL TSTSPRAPSR QSSTATSSSS TGGSIRRFSF
ARAEPGCLVP SPPPPYTTSH SIHLAQPSGF LVSPQYFAYP LQQEPPLPGK SCPDFSSS
